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Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing
Analysis of bone metastasis of prostatic
adenocarcinoma
in 137 autopsy cases. Adv. Exp. Med.
Analysis of bone metastasis of prostatic
adenocarcinoma
in 137 autopsy cases. Adv. Exp. Med.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
More information on Lu PSMA treatment failure
I think the new growth is
adenocarcinoma
that isn't expressing PSMA. I'm not sure what this means in terms of how the treatment could have been made more effective. There seems to be anecdotal evidence that combining enzalutamide with Lu PSMA yields better benefit, but the sample size is small.
I think the new growth is
adenocarcinoma
that isn't expressing PSMA. I'm not sure what this means in terms of how the treatment could have been made more effective. There seems to be anecdotal evidence that combining enzalutamide with Lu PSMA yields better benefit, but the sample size is small.
Javelin18
in
Advanced Prostate Cancer
2 years ago
On Active Surveillance - Why not non-invasive aggressive approach?
Result confirms same as June biopsy of
Adenocarcinoma
Gleason 6, Grade 1 in about 5 cores (including 1 in ROI) at 30% and PSA holding at 2.6 for a year now. Urologist says active surveillance and to see him in 6 moonths / PSA. I'm going to get an annual physical and full blood workup.
Result confirms same as June biopsy of
Adenocarcinoma
Gleason 6, Grade 1 in about 5 cores (including 1 in ROI) at 30% and PSA holding at 2.6 for a year now. Urologist says active surveillance and to see him in 6 moonths / PSA. I'm going to get an annual physical and full blood workup.
Shagaru
in
Prostate Cancer Network
2 years ago
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Lung infections after Lobectomy?
I have had the most amazing support from people on this forum particularly from Loimie and Zac and want to say thank you so much for helping me through since I was first diagnosed with
Adenocarcinoma
in my top right lung . I'm not going to go through everything again (!)
I have had the most amazing support from people on this forum particularly from Loimie and Zac and want to say thank you so much for helping me through since I was first diagnosed with
Adenocarcinoma
in my top right lung . I'm not going to go through everything again (!)
Danni54
in
The Roy Castle Lung Cancer Foundation
2 years ago
Serotonin Makes Tumors Happy Too
Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder,
adenocarcinoma
of the prostate and renal cell carcinoma.
Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder,
adenocarcinoma
of the prostate and renal cell carcinoma.
Hidden
in
Advanced Prostate Cancer
2 years ago
RP 2019 now rising PSA and PSMA with most likely metastatic lymph node- any comments or advice on treatment plan?
Below is pathology from RP- Prostate (Radical Prostatectomy, TS-19-05686, 2/4/2019): HISTOLOGIC TYPE
Adenocarcinoma
(conventional, NOS) GLEASON SCORE, DOMINANT NODULE 3+4=7 Grade Group 2 40% Pattern 4 (tertiary pattern 5) TUMOR EXTENT Tumor dimension (max): 24.0 mm LOCATION, DOMINANT NODULE
Below is pathology from RP- Prostate (Radical Prostatectomy, TS-19-05686, 2/4/2019): HISTOLOGIC TYPE
Adenocarcinoma
(conventional, NOS) GLEASON SCORE, DOMINANT NODULE 3+4=7 Grade Group 2 40% Pattern 4 (tertiary pattern 5) TUMOR EXTENT Tumor dimension (max): 24.0 mm LOCATION, DOMINANT NODULE
WickedNeptune
in
Prostate Cancer Network
2 years ago
GPM6B Inhibit PCa Proliferation by Blocking Prostate Cancer Cell Serotonin Absorptive Capacity
Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder,
adenocarcinoma
of the prostate and renal cell carcinoma.
Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder,
adenocarcinoma
of the prostate and renal cell carcinoma.
Hidden
in
Advanced Prostate Cancer
2 years ago
PSA following ADT and RT
He was diagnosed with a gleason 8
adenocarcinoma
with local spread to the lymph nodes, EPE+, right SVI+, psa 308.
He was diagnosed with a gleason 8
adenocarcinoma
with local spread to the lymph nodes, EPE+, right SVI+, psa 308.
Pcsurvival89
in
Advanced Prostate Cancer
2 years ago
Extracts from two papers on exercise and cancer. Paper 1 investigates the blood from 25 patients with mCRPC exercising. Paper 2 is a review.
Briefly, patients who had been identified as mCRPC (
adenocarcinoma
of the prostate with systemic metastatic disease despite castrate levels of testosterone (<50 ng/dl) due to orchiectomy or luteinising hormone-releasing hormone (LHRH) agonist, undergoing ADT (gonadotropin-releasing hormone (GnRH) agonist
Briefly, patients who had been identified as mCRPC (
adenocarcinoma
of the prostate with systemic metastatic disease despite castrate levels of testosterone (<50 ng/dl) due to orchiectomy or luteinising hormone-releasing hormone (LHRH) agonist, undergoing ADT (gonadotropin-releasing hormone (GnRH) agonist
Graham49
in
Advanced Prostate Cancer
2 years ago
CoQ10 Good or Bad? Necessary? Reaching a Conclusion, Coenzyme Q10, Statins, Prostate Cancer
., In vivo metabolic tracing to demonstrate that pancreatic ductal
adenocarcinoma
(PDAC) tumors rely on the mevalonate pathway to synthesize CoQ de novo.
., In vivo metabolic tracing to demonstrate that pancreatic ductal
adenocarcinoma
(PDAC) tumors rely on the mevalonate pathway to synthesize CoQ de novo.
jazj
in
Advanced Prostate Cancer
2 years ago
The Patch Trial...The Verdict is in!
Transdermal oestradiol for androgen suppression in prostatecancer: long-term cardiovascular outcomes from the randomised Prostate
Adenocarcinoma
Transcutaneous Hormone (PATCH) trial programme.
Transdermal oestradiol for androgen suppression in prostatecancer: long-term cardiovascular outcomes from the randomised Prostate
Adenocarcinoma
Transcutaneous Hormone (PATCH) trial programme.
E2-Guy
in
Advanced Prostate Cancer
2 years ago
What does recent biopsy mean positive for NKX3.1?
Results reveal tumor cells in iliac node positive for NKX 3.1 while INSM1 & synaptophysin "show very rare positive cells." and
adenocarcinoma
in one lung. A chromogranin A test shows an upward trend, from 52 (9/20) to 86 (11/21). We're meeting with his oncologist tomorrow.
Results reveal tumor cells in iliac node positive for NKX 3.1 while INSM1 & synaptophysin "show very rare positive cells." and
adenocarcinoma
in one lung. A chromogranin A test shows an upward trend, from 52 (9/20) to 86 (11/21). We're meeting with his oncologist tomorrow.
julyturqsee
in
Advanced Prostate Cancer
2 years ago
Biopsy results of my father. Help with suggesting what I should be looking at.
Apex :
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% D: Lat Base :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 60% (May be PNI) E:Lat Mid :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 65% F: Lat Apex:
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% G: Target
Apex :
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% D: Lat Base :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 60% (May be PNI) E:Lat Mid :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 65% F: Lat Apex:
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% G: Target
DRKC81
in
Prostate Cancer Network
2 years ago
Biopsy results post MRI . Help with suggestions on read up and treatment options ( Gleason 3 + 4)
Apex :
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% D: Lat Base :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 60% (May be PNI) E:Lat Mid :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 65% F: Lat Apex:
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% G: Target
Apex :
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% D: Lat Base :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 60% (May be PNI) E:Lat Mid :
Adenocarcinoma
(Gleason 7 (3+4)) Tumor length percent 65% F: Lat Apex:
Adenocarcinoma
(Gleason 6 (3+3)) Tumor length percent 50% G: Target
DRKC81
in
Advanced Prostate Cancer
2 years ago
High Gleason, Low PSA
Biopsy from TURP: Prostatic
adenocarcinoma
, Gleason score 4+5=9 (Grade Group 5), involving approximately 90% of submitted tissue. Focal mucinous features. Perineural invasion identified in this case. Intraductal carcinoma of the prostate identified.
Biopsy from TURP: Prostatic
adenocarcinoma
, Gleason score 4+5=9 (Grade Group 5), involving approximately 90% of submitted tissue. Focal mucinous features. Perineural invasion identified in this case. Intraductal carcinoma of the prostate identified.
mysticmini
in
Advanced Prostate Cancer
2 years ago
Got PSMA SCAN Results-Now What?
On March 5, 2021 I received the results which indicated
adenocarcinoma
prostate cancer, with three Gleason score 8s and two 9s.
On March 5, 2021 I received the results which indicated
adenocarcinoma
prostate cancer, with three Gleason score 8s and two 9s.
Skippy3
in
Advanced Prostate Cancer
2 years ago
Lu-177 in Austria - Report and underlining high importance of both FDG and PSMA PET/CTs
Summary of the Lu-177 treatment report: _________ "Indication: Prostate
adenocarcinoma
via biopsy July 2020 (Alta Klinik Bielefeld). Gleason score 4+4=8. Volume >800ml. Lymph node metastases and suspicious bone lesions. PSA at ID >1,600ng/ml, peaked up to 13,000ng/ml.
Summary of the Lu-177 treatment report: _________ "Indication: Prostate
adenocarcinoma
via biopsy July 2020 (Alta Klinik Bielefeld). Gleason score 4+4=8. Volume >800ml. Lymph node metastases and suspicious bone lesions. PSA at ID >1,600ng/ml, peaked up to 13,000ng/ml.
CurrentSEO
in
Advanced Prostate Cancer
2 years ago
When Active Surveillance is not Active
Who diligently performed Active Surveillance protocol for my diagnosis of a Gleason 6
adenocarcinoma
. Anyway you would have thought by this GP response to my request that I was asking him for half of his weekly earnings.
Who diligently performed Active Surveillance protocol for my diagnosis of a Gleason 6
adenocarcinoma
. Anyway you would have thought by this GP response to my request that I was asking him for half of his weekly earnings.
Aussieguy1
in
Prostate Cancer And Gay Men
2 years ago
HRT and Ovarian Cancer
Stage 1c endometriod
adenocarcinoma
at the age of 41. I was told I wasn't allowed HRT and assumed they meant forever.. so I figured out ways to help my body get through the menopause. Now just over a year later I'm doing great.
Stage 1c endometriod
adenocarcinoma
at the age of 41. I was told I wasn't allowed HRT and assumed they meant forever.. so I figured out ways to help my body get through the menopause. Now just over a year later I'm doing great.
Nara42
in
My Ovacome
2 years ago
Dostarlimab shows efficacy as curative-intent treatment in rectal cancer subset
Fourteen patients (median age, 54 years; 67% women; 61% white) with mismatch repair-deficient stage II and stage III rectal
adenocarcinoma
received dostarlimab every 3 weeks for 6 months, followed by standard chemoradiation and surgery.
Fourteen patients (median age, 54 years; 67% women; 61% white) with mismatch repair-deficient stage II and stage III rectal
adenocarcinoma
received dostarlimab every 3 weeks for 6 months, followed by standard chemoradiation and surgery.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
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