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Acalabrutinib
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Acalabrutinib/Calquence
Patients in England with an incurable blood cancer will have access to
acalabrutinib
after it was approved by the National Institute for Health and Care Excellence. Reproduced from today's i newspaper.
Patients in England with an incurable blood cancer will have access to
acalabrutinib
after it was approved by the National Institute for Health and Care Excellence. Reproduced from today's i newspaper.
SERVrider
in
Positive Wellbeing During Self-Isolation
3 years ago
Telephone consultation
Acalabrutinib
will be drug of choice now that it has been approved by NICE 😘😘
Acalabrutinib
will be drug of choice now that it has been approved by NICE 😘😘
kitchengardener2
in
CLL Support
3 years ago
New to Acalabrutinib
However, because my neutrophil count has been very low for the last couple of years, my oncologist suggested starting on
Acalabrutinib
to reduce the risk for a potential severe bacterial infection.
However, because my neutrophil count has been very low for the last couple of years, my oncologist suggested starting on
Acalabrutinib
to reduce the risk for a potential severe bacterial infection.
Vizilo
in
CLL Support
3 years ago
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Acalabrutinib used by NHS
I'm sure someone has written abt this but just in case: https://www.europeanpharmaceuticalreview.com/news/147977/new-oral-chronic-lymphocytic-leukaemia-treatment-made-available-on-nhs/ I know this has been around for a while in the US but nice to see progress all the time in the UK. I think from what
I'm sure someone has written abt this but just in case: https://www.europeanpharmaceuticalreview.com/news/147977/new-oral-chronic-lymphocytic-leukaemia-treatment-made-available-on-nhs/ I know this has been around for a while in the US but nice to see progress all the time in the UK. I think from what
Research123
in
CLL Support
3 years ago
Low body temperature and low grade chills on acalabrutinib.
I am on
acalabrutinib
since September 1st. My blood counts are moving in a right direction, but my spleen did not shrink much , and I feel fullness in my abdomen area. The other major concern is my low body temperature, sometimes 34 and below, (or 94 and below) .with low grade chills.
I am on
acalabrutinib
since September 1st. My blood counts are moving in a right direction, but my spleen did not shrink much , and I feel fullness in my abdomen area. The other major concern is my low body temperature, sometimes 34 and below, (or 94 and below) .with low grade chills.
Belkin123
in
CLL Support
3 years ago
Does anyone has enlarged liver on acalabrutinib?
I am wondering if anyone has enlarged liver on
acalabrutinib
. I am on
acalabrutinib
since September 1st. My blood tests are much improved, but I feel now more pressure on the right side than the left side. Can
acalabrutinib
effect liver? My spleen decreased only slightly from 21 cm to 17cm.
I am wondering if anyone has enlarged liver on
acalabrutinib
. I am on
acalabrutinib
since September 1st. My blood tests are much improved, but I feel now more pressure on the right side than the left side. Can
acalabrutinib
effect liver? My spleen decreased only slightly from 21 cm to 17cm.
Belkin123
in
CLL Support
3 years ago
Clinical trial with Acalabrutinib and Obinutuzumab
The targeted therapy is
Acalabrutinib
and Obinutuzumab. I would appreciate hearing from people that have had these two drugs. What was your experience? I am struggling with the decision of whether to participate in the trial. Thanks.
The targeted therapy is
Acalabrutinib
and Obinutuzumab. I would appreciate hearing from people that have had these two drugs. What was your experience? I am struggling with the decision of whether to participate in the trial. Thanks.
Reflectionofsky
in
CLL Support
3 years ago
Bladder Cancer with CLL
CLL since 2012 ( Ibrutinib 5 years , Gayzva 6 months ,
Acalabrutinib
2 years ) now bladder cancer , high grade , no wall penetration .... advised to take BCG for 6 weeks every 3 months for a year ... anyone shed light on what I can physically expect from the BCG ?
CLL since 2012 ( Ibrutinib 5 years , Gayzva 6 months ,
Acalabrutinib
2 years ) now bladder cancer , high grade , no wall penetration .... advised to take BCG for 6 weeks every 3 months for a year ... anyone shed light on what I can physically expect from the BCG ?
fish61
in
CLL Support
3 years ago
Acalabrutinib exhibits comparable efficacy, superior safety to ibrutinib for CLL (finally!)
[i]Positive high-level results from the ELEVATE-RR Phase III trial showed AstraZeneca’s Calquence (
acalabrutinib
) met the primary endpoint demonstrating non-inferior progression-free survival (PFS) for adults with previously treated, high-risk chronic lymphocytic leukaemia (CLL) compared to ibrutinib
[i]Positive high-level results from the ELEVATE-RR Phase III trial showed AstraZeneca’s Calquence (
acalabrutinib
) met the primary endpoint demonstrating non-inferior progression-free survival (PFS) for adults with previously treated, high-risk chronic lymphocytic leukaemia (CLL) compared to ibrutinib
avzuclav
in
CLL Support
3 years ago
Acalabrutinib Plus Obinutuzumab Prolongs Progression Free Survival Compared to Other Targeted Agents in Chronic Lymphocytic Leukaemia (CLL)
[i]First-line
acalabrutinib
plus obinutuzumab prolongs progression-free survival (PFS) compared to ibrutinib-obinutuzumab and venetoclax-obinutuzumab for patients with chronic lymphocytic leukemia (CLL), according to a study published in Clinical Lymphoma, Myeloma, & Leukemia (2020 Oct 29;S2152-2650(
[i]First-line
acalabrutinib
plus obinutuzumab prolongs progression-free survival (PFS) compared to ibrutinib-obinutuzumab and venetoclax-obinutuzumab for patients with chronic lymphocytic leukemia (CLL), according to a study published in Clinical Lymphoma, Myeloma, & Leukemia (2020 Oct 29;S2152-2650(
AussieNeil
Partner
in
CLL Support
3 years ago
ibrutinib, acalabrutinib, covid, vaccine
https://www.clinicaloptions.com/infectious-disease/programs/covid-and-cll/faq-module/faq/page-1
https://www.clinicaloptions.com/infectious-disease/programs/covid-and-cll/faq-module/faq/page-1
Mik_
in
CLL Support
3 years ago
Re vaccine and outcome for CLL you might find this interesting
., ibrutinib,
acalabrutinib
) were less likely to make antibodies after vaccination. Those patients with less IgA antibodies in their blood in general (meaning they struggle to make antibodies to many diseases) were also less likely to form antibodies after vaccination.
., ibrutinib,
acalabrutinib
) were less likely to make antibodies after vaccination. Those patients with less IgA antibodies in their blood in general (meaning they struggle to make antibodies to many diseases) were also less likely to form antibodies after vaccination.
Lookintomyeyes
in
CLL Support
3 years ago
Reduced dose Acalabrutinib
Acalabrutinib
keeps my CLL in check but gives me neutropenia. One strategy would be to cut the usual dose in half to 100 mg/day. Does anyone have experience with this dose? Is it possible that a dose that low could be effective?
Acalabrutinib
keeps my CLL in check but gives me neutropenia. One strategy would be to cut the usual dose in half to 100 mg/day. Does anyone have experience with this dose? Is it possible that a dose that low could be effective?
john-doe
in
CLL Support
4 years ago
Good end to a bad year... My MRD Results are in!
ClinicalTrials.gov Identifier: NCT04016805 Recruitment Status : Recruiting First Posted : July 11, 2019 Last Update Posted : December 2, 2020 Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Subjects With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib,
Acalabrutinib
ClinicalTrials.gov Identifier: NCT04016805 Recruitment Status : Recruiting First Posted : July 11, 2019 Last Update Posted : December 2, 2020 Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Subjects With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib,
Acalabrutinib
MikeHoff
in
CLL Support
3 years ago
Acalabrutinib approved
Hi everyone As of November 25 ,
Acalabrutinib
has been approved as a mono therapy for second line treatment in France for patients not doing well on Ibrutinib.
Hi everyone As of November 25 ,
Acalabrutinib
has been approved as a mono therapy for second line treatment in France for patients not doing well on Ibrutinib.
Sergi
in
CLL Support
4 years ago
Looking for a fifth line of CLL treatment
I’m 55 and on my fourth line of treatment in 4 years: BR, Ibrutinib, Venetoclax,
Acalabrutinib
. And it looks like I’ll need a fifth soon. The
acalabrutinib
keeps the CLL in check but gives me neutropenia. Stopping acalacbrutinib for a week raised my ANC from 0.6 to 2.0.
I’m 55 and on my fourth line of treatment in 4 years: BR, Ibrutinib, Venetoclax,
Acalabrutinib
. And it looks like I’ll need a fifth soon. The
acalabrutinib
keeps the CLL in check but gives me neutropenia. Stopping acalacbrutinib for a week raised my ANC from 0.6 to 2.0.
john-doe
in
CLL Support
4 years ago
Has anyone been prescribed and started Acalabrutinib and venetoclax treatment in U.K. in 2020
I have been told I am ready to start treatment but it has been deferred because of the Covid 19 status in the UK hospital where I go to see my haematologist .. has anyone else experienced this ?
I have been told I am ready to start treatment but it has been deferred because of the Covid 19 status in the UK hospital where I go to see my haematologist .. has anyone else experienced this ?
Tupence
in
CLL Support
3 years ago
Leg Cramps
Multiple treatments, now on
acalabrutinib
with good results. Some headaches and dizziness are the side effects. My problem has been leg cramps for years, now becoming more intense and problematic at night or when reclining. Not an issue while upright during the day.
Multiple treatments, now on
acalabrutinib
with good results. Some headaches and dizziness are the side effects. My problem has been leg cramps for years, now becoming more intense and problematic at night or when reclining. Not an issue while upright during the day.
BallyB
in
CLL Support
4 years ago
COVID-19 Vaccinations Opinion from Dr. R. Furman MD (cross posted from CLLSLL@groups.io with his permission )
The
acalabrutinib
trial in COVID-19 (non-CLL patients) did not show a benefit, but there were some issues with that trial that might not make it generalizable to everyone. I suspect that BTK inhibitors do help and have been continuing my patients on them.
The
acalabrutinib
trial in COVID-19 (non-CLL patients) did not show a benefit, but there were some issues with that trial that might not make it generalizable to everyone. I suspect that BTK inhibitors do help and have been continuing my patients on them.
lankisterguy
Volunteer
in
CLL Support
3 years ago
Obinutuzumab and Venetoclax cleared for use in UK
I think I read somewhere that this is also sometimes combined with ibrutinib or
acalabrutinib
?
I think I read somewhere that this is also sometimes combined with ibrutinib or
acalabrutinib
?
Research123
in
CLL Support
4 years ago
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