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Experiences with
Acalabrutinib
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Incorrect Interpretation of BTKis & Incidence of SPM
They concluded that neither ibrutinib nor
acalabrutinib
altered the incidence of secondary primary malignancies in CLL patients.
They concluded that neither ibrutinib nor
acalabrutinib
altered the incidence of secondary primary malignancies in CLL patients.
gardening-girl
in
CLL Support
2 years ago
acalabrutinib stopped working. Can switching to venclexta help?
I am on
acalabrutinib
for two years. In first year my wbc went down from 150k to 18k, and for the second year from from 18k to 14k. My hgb is 15, plt 200k. My spleen decreased in size from 21cm to 14cm. I feel generally better, and no side effects. My dr think about switching to venclexta.
I am on
acalabrutinib
for two years. In first year my wbc went down from 150k to 18k, and for the second year from from 18k to 14k. My hgb is 15, plt 200k. My spleen decreased in size from 21cm to 14cm. I feel generally better, and no side effects. My dr think about switching to venclexta.
Belkin123
in
CLL Support
2 years ago
Navigating the Hidden Costs of Clinical Trials on Patient Power
After enrollment, he was given a three-drug combination treatment of obinutuzumab (Gazyva), venetoclax (Venclexta), and
acalabrutinib
(Calquence).
After enrollment, he was given a three-drug combination treatment of obinutuzumab (Gazyva), venetoclax (Venclexta), and
acalabrutinib
(Calquence).
lankisterguy
Volunteer
in
CLL Support
2 years ago
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SLL and Acalabrutinib
Hi , I have SLL and started on
Acalabrutinib
in January 2022, unfortunately got Covid at end of Feb so off treatment for 6 weeks at that time. Pre treatment my Hb level was at 146 and Lymphocytes at 7.9.
Hi , I have SLL and started on
Acalabrutinib
in January 2022, unfortunately got Covid at end of Feb so off treatment for 6 weeks at that time. Pre treatment my Hb level was at 146 and Lymphocytes at 7.9.
uide3095
in
CLL Support
2 years ago
Starting Acalabrutinib from today.
Biggiest lymp node is around in 13.5cm in abdomen, so doctor told to start
Acalabrutinib
. He is TP53 positive and IGVH unmutated.
Biggiest lymp node is around in 13.5cm in abdomen, so doctor told to start
Acalabrutinib
. He is TP53 positive and IGVH unmutated.
pbaddi
in
CLL Support
2 years ago
Acalabrutinib (4 month update) + Obinutuzumab ?
For starters, a quick
Acalabrutinib
update. I started
acalabrutinib
~ 4 months ago and my nodes and spleen are normal again (took only a few weeks) and my HGB and PLT counts are in normal range. My WBC is at 16 during last checkup, but much better than the 150 when I started.
For starters, a quick
Acalabrutinib
update. I started
acalabrutinib
~ 4 months ago and my nodes and spleen are normal again (took only a few weeks) and my HGB and PLT counts are in normal range. My WBC is at 16 during last checkup, but much better than the 150 when I started.
Flitzebogen
in
CLL Support
2 years ago
Reduced Dose of Acalabrutinib
I am on a 50% reduction of
Acalabrutinib
(once a day). Does anyone know if this will also reduce the irreversible binding of the drug and therefore accelerate resistance o eh drug? Is there any data on this? Thanks.
I am on a 50% reduction of
Acalabrutinib
(once a day). Does anyone know if this will also reduce the irreversible binding of the drug and therefore accelerate resistance o eh drug? Is there any data on this? Thanks.
naddude
in
CLL Support
2 years ago
starting acalabrutinib while waiting for pirtobrutinib to be FDA approved
They are starting him on
acalabrutinib
and rituxin . He is exceptionally weak. And fairly discouraged. Has anyone been down this path?
They are starting him on
acalabrutinib
and rituxin . He is exceptionally weak. And fairly discouraged. Has anyone been down this path?
KLWC
in
CLL Support
2 years ago
BTK Interruption & Disease Flare
I went off
acalabrutinib
nine days ago in preparation for a surgery - I was told to hold the medication for seven days before and after. Already the lymph nodes in my neck have started to swell. They hurt and I can feel them with my fingers, about the size of kidney beans.
I went off
acalabrutinib
nine days ago in preparation for a surgery - I was told to hold the medication for seven days before and after. Already the lymph nodes in my neck have started to swell. They hurt and I can feel them with my fingers, about the size of kidney beans.
Amberesque
in
CLL Support
2 years ago
Acalabrutinib - single dose regime
Hello, I have been on 1 cycle of alacabrutinib (28 days). Total WBC count initially rose from 140 to 300 (x 10^9/L), now down to 200. Have had problems with bruising and bleeding (platelets 60 to 80). Consultant suggests going from 2 x 100mg/day, down to a single dose of 100mg PD. However my (ancient
Hello, I have been on 1 cycle of alacabrutinib (28 days). Total WBC count initially rose from 140 to 300 (x 10^9/L), now down to 200. Have had problems with bruising and bleeding (platelets 60 to 80). Consultant suggests going from 2 x 100mg/day, down to a single dose of 100mg PD. However my (ancient
Virosafe2001
in
CLL Support
2 years ago
Ibrutinib to Acalabrutinib
My oncologist is switching me from IB to Calquence because I had some irregular heart activity. I have been on IB for 3.6 years and it has been very good for me. My question is have you also switched and how have you found it? When you started Calaquence was it a gradual weaning off IB or did you switch
My oncologist is switching me from IB to Calquence because I had some irregular heart activity. I have been on IB for 3.6 years and it has been very good for me. My question is have you also switched and how have you found it? When you started Calaquence was it a gradual weaning off IB or did you switch
steve_canada
in
CLL Support
2 years ago
Had telephone consultation this morning.
Dr Munro (my consultant) said to continue with the Apixaban since it was ok with
Acalabrutinib
until after I have seen the cardiologist and then she will review the situation. I said I was quite happy to take anything which was necessary but didn't want to take unnecessary drugs.
Dr Munro (my consultant) said to continue with the Apixaban since it was ok with
Acalabrutinib
until after I have seen the cardiologist and then she will review the situation. I said I was quite happy to take anything which was necessary but didn't want to take unnecessary drugs.
kitchengardener2
in
CLL Support
2 years ago
SKIN WELTS!
Eventually they subsided, and I began treatment with
acalabrutinib
16 months ago. However, three months ago those welts started appearing once more, and it's still happening even though I'm temporarily off meds in preparation for surgery.
Eventually they subsided, and I began treatment with
acalabrutinib
16 months ago. However, three months ago those welts started appearing once more, and it's still happening even though I'm temporarily off meds in preparation for surgery.
Amberesque
in
CLL Support
2 years ago
Low Blood Sodium When On BTK Inhibitors
Wondering if anyone has developed low sodium levels while on
Acalabrutinib
, Ibrutinib, or Zanubrutinib. We are told to drink plenty of water while on these medications. My sodium levels have been dropping over the last few months. I know this can be caused by many things.
Wondering if anyone has developed low sodium levels while on
Acalabrutinib
, Ibrutinib, or Zanubrutinib. We are told to drink plenty of water while on these medications. My sodium levels have been dropping over the last few months. I know this can be caused by many things.
Davidcara
in
CLL Support
2 years ago
Possible AF
I told him I had
Acalabrutinib
and asked if it would be ok, he said he wasn’t up to speed with
Acalabrutinib
. I was reluctant to take medication without speaking to my Haematology Consultant. I was discharged from hospital after my leg was dressed.
I told him I had
Acalabrutinib
and asked if it would be ok, he said he wasn’t up to speed with
Acalabrutinib
. I was reluctant to take medication without speaking to my Haematology Consultant. I was discharged from hospital after my leg was dressed.
kitchengardener2
in
AF Association
2 years ago
Life without Ibrutinib
He has decided to let me run without treatment until we start to see doubling rate increase, then switch me to
Acalabrutinib
. Right now I’m in remission, and I’m waiting for the results of my MRD to see how long I can stay off treatment.
He has decided to let me run without treatment until we start to see doubling rate increase, then switch me to
Acalabrutinib
. Right now I’m in remission, and I’m waiting for the results of my MRD to see how long I can stay off treatment.
MovingForward4423
in
CLL Support
2 years ago
Acalabrutinib versus Covid19?
Various reports suggest that CLL patients in clinical trials prescribed
Acalabrutinib
who contract covid 19 are surviving well due the anti inflammatory impact on the covid 19 virus as a result of the
Acalabrutinib
?
Various reports suggest that CLL patients in clinical trials prescribed
Acalabrutinib
who contract covid 19 are surviving well due the anti inflammatory impact on the covid 19 virus as a result of the
Acalabrutinib
?
spanish36
in
CLL Support
2 years ago
Further evidence that even moderate exercise is good for your long term health - particularly when you have CLL!
[/i]https://insidemedicine.substack.com/p/weekend-warriors-vs-daily-gym-rats (no registration required) While BTK inhibitor therapy with the 'inib drugs (
acalabrutinib
, ibrutinib and zanubrutinib, with pirtobrutinib and others on the way), has dramatically changed survival times with CLL, these treatments
[/i]https://insidemedicine.substack.com/p/weekend-warriors-vs-daily-gym-rats (no registration required) While BTK inhibitor therapy with the 'inib drugs (
acalabrutinib
, ibrutinib and zanubrutinib, with pirtobrutinib and others on the way), has dramatically changed survival times with CLL, these treatments
AussieNeil
Partner
in
CLL Support
11 months ago
Managing the cardiovascular risk of Bruton's Tyrosine Kinase Inhibitors in chronic lymphocytic leukemia
Low risk cases may be safely treated with BTKis; Favor more 2nd-generation BTKis (
acalabrutinib
or zanubrutinib) or alternative treatments. BTKi treatment may be continued in consultation with MDT for patients with: Permanent/persistent AF, HTN, History of myocardial infarction.
Low risk cases may be safely treated with BTKis; Favor more 2nd-generation BTKis (
acalabrutinib
or zanubrutinib) or alternative treatments. BTKi treatment may be continued in consultation with MDT for patients with: Permanent/persistent AF, HTN, History of myocardial infarction.
CLLerinOz
Administrator
in
CLL Support
2 years ago
Reduced DOSE of Acalabrutinib/Calquence
HAs anyone been offered a reduced dose of Calquence - other than the 100mg that it comes as standard? thanks
HAs anyone been offered a reduced dose of Calquence - other than the 100mg that it comes as standard? thanks
Brucex100
in
CLL Support
2 years ago
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