[CASE-STUDY] Sweet’s syndrome triggered by ultraviolet light

[Shell567]

Case 2. Patient didn't respond to steroids or several other treatments.

"A diagnosis of photoinduced Sweet’s syndrome was made. Different treatments were prescribed (systemic corticosteroids, hydroxychloroquine and doxycycline) with no results. A second-line treatment such as dapsone was chosen. This drug interferes with the myeloperoxidase-halide system that generates oxygen intermediates so it can be used in neutrophil-mediated skin diseases such as Sweet syndrome. However, it was ineffective. The patient did not tolerate methotrexate or azathioprine. Due to the patient’s poor response to treatment, adalimumab 40 mg was started every week, with an excellent clinical response after six months. No relapses have been noted after six months of follow-up."

Click on Full Text tab to access full article. sciencedirect.com/science/a...

[Anna2131p]

Hi I was on Colchine first but it wasn’t helping and my body rejected it,they then altered me to dapsone I become very poorly tha my Gp contacted my team and they admitted me into hospital due to the bad reaction that my body had I become very swollen barely able to walk and had worse flare up that I was kept in for 13 days as my crp levels were so high,and bp and couldn’t stay awake .. So they stopped Dapsone immediately as felt my body had bad reaction and had another punch biopsy..

[Shell567 Administrator Sweet's Syndrome UK in reply to Anna2131p]

Hi Anna,

Sorry to hear you didn't respond well to dapsone. Mine was stopped due to side-effects. Never tried colchicine.

[Shell567 Administrator Sweet's Syndrome UK]

Info for members new to dapsone dermnetnz.org/topics/dapsone/

[Shell567 Administrator Sweet's Syndrome UK]

Photosensitive Sweet syndrome: An uncommon entity, Indian Journal of Dermatology, Venereology and Leprology 2022.

"Photo-induction and photo-aggravation of Sweet syndrome have been described previously. Lesions consistent with Sweet syndrome can be induced by both ultraviolet-B (290 nm) and ultraviolet-A (340–400 nm) radiation on phototesting." ijdvl.com/photosensitive-sw...