Ocular manifestations of dermal paraneoplastic syndromes.
- Ocular involvement in Sweet's syndrome is ranged from 4% to 72%. Mainly conjunctivitis or episcleritis.
- Also, scleritis, subconjunctival haemorrhage, glaucoma (inflammatory glaucoma), orbital as well as periorbital and eyelid inflammation, eruptions, dacryoadenitis, limbal nodules, peripheral ulcerative keratitis, iritis, choroiditis, retinal vasculitis and occlusive vasculitis.
- Severe bilateral chemosis (swelling of the conjunctiva) as the first sign of recurrent Sweet's syndrome in a patient with stable skin lesions and rapid improvement after steroid therapy started.
- Case of bilateral panuveitis and papillitis with secondary macular oedema in the left eye in neuro-Sweet's syndrome. This variant of Sweet's syndrome usually presents with CNS involvement (meningitis or encephalitis).
- In half of cases, just one eye is affected.
- Eye symptoms usually appear at the same time or several days after skin lesions. However, there is a case of Sweet's syndrome in which the patient developed nodular scleritis and peripheral ulcerative keratitis during the dermatologically inactive period (no skin lesions) of the disease. Treatment with fluorometholone 0.1%, ofloxacin 0.3% and artificial tear eye drops 5 times a day together with oral fluocortolone worked well. ncbi.nlm.nih.gov/pmc/articl...