Just wondering if anyone has experience of taking PPIs for a long time... I've been using them off and on now, for a couple of years to manage acid reflux, and trying to fill pill breaks with a strict diet and gaviscon advance. But the reflux is getting worse and my GP wants me to go onto a permanent daily PPI now. I'm in my 40s, so I guess I could potentially could be on them for a while. But I'm a bit worried about this because of all the stuff I've read about possible long-term side effects from taking a permanent PPI...Even the leaflet in the box is scary. I've read about osteoporosis, kidney problems and even stomach cancer. But I know the alternative of not taking them is potential oesophageal cancer from acid in throat. As always with scleroderma, we're stuck between a rock and a hard place. Anyway, just wondering whether anyone who has taken a PPI for a long time can tell me how they're getting on with them. Do you get regular endoscopies to keep an eye on you? Any advice would be much appreciated. Thanks so much.