treatment path after Ibrance U.K.

[TE53_67]

I am under GSTT in London and on Ibrance and Letrozole currently. I wanted to see with ER and PR positive and Her- what treatment paths had been offered to the community after Ibrance. Xx

[Autum1]

Hi. I'm in the UK. Was on Ibrance and Letrozole since diagnosis they stopped working after 14 months. Due to rapidly increasing liver mets I was told my only option was IV chemo. I'm now on weekly Taxol which I started 4 weeks ago. So far it's not been as bad as I thought. I'm also ER/PR positive her2 negative.

[kiwi67]

Hi. I'm from New Zealand. I am ER and PR positive HER2 low. I have been on treatment with Ibrance and Fulvestrant for about a year but 3 weeks ago my scan showed liver mets increasing so I'm being changed to Capecitabine, an oral chemo. Just waiting for blood test results for special enzyme test. After Cape. I will be offered "vanilla bean" ( that's what we call it because its name is way toooooooooooooo tricky) it is also another oral chemo. After that a good drug for HER2 is Enhertu (its IV) but its not funded yet in NZ and would cost me $150,000. I'm hopeful that by the time I need that it will be funded. This nightmare is a roller coaster of shitte, we just have to go with. I hope your next treatment is very good at holding your mets at bay, all the best. Susan

[Bella_mum in reply to kiwi67]

Hi Susan,

I’m in Canada - got 4 years on Ibrance and Lettozole but spread to my liver prompted a change. I too want the Enhertu but it’s not cleared here yet so not funded. I’ve switched to Everolimus and Exemestane so we’ll see how that goes, Cape might be an option next if the new drug still isnt available.

Good luck!

[POT2018ery]

I am treated with Ibrance 125 and faslodex. I have no real side effects. I’ve been doing this for 6 years. Don’t give. Up

[HelenWi]

There are multiple targeted therapies available after Ibrance and before chemo, provided you have specific mutations. So after progression, it’s useful to do a genetic blood test such as Guardant to determine if you have mutations such as pik3ca, akt1, Pten, esr1, etc.

best,

Helen

[Beryl71]

I managed to stay on ibrance but changed letrozole to fulvestrant and that has worked for me. Good luck!

[Lilywallytootsie]

Great question. I have been on Ibrance/Letrozole for a little over seven years and have been curious about that too. Guess we have to wait until it happens and be tested before a decision can be made. Hope all goes well for you. Blessings, Hannah

[TE53_67]

ditto ❤️

I’ve been on Ibrance for 6 years. I will ask at my next appointment though

[Iwasborntodothis]

My path after Ibrance was:

Faslodex - 8 weeks

Capcetibine/Xeloda (pill) - 12 months

Taxol (IV) - 12 months

Carboplatin (IV) - 8 weeks

Trodelvy (IV) - 14 months

[TE53_67 in reply to Iwasborntodothis]

Sorry meant to reply here !

Wow

Are you also er and or positive and hers negative ?xx