Copied from under "Abstract" paragraph: Palbociclib, 5-days-on/2-days-off weekly, met its primary endpoint with reduced G3 + ANC, without compromising efficacy. sTK1 is prognostic and shows promise in monitoring the palbociclib response. ClinicalTrials.gov#: NCT3007979.
Here's the whole article. If I could remember who was asking for this, I would have sent to you directly! God bless you and heal us all in Jesus name, amen. PS I have been on this schedule for 10 mos. and doing very well. PS. My onc said "no" to this also, my body my choice! QOL here!
Yes, I never get that "so tired" feeling I used to get with ibrance back in 2019. I had taken it for 6 mos. and had chest pains and high blood pressure. I thought it was the ibrance but now I know it was the Letrozole causing that. Anyway, I panicked and quit taking it and just started again 10 mos. ago because it had never stopped working, that wasn't why I had stopped it! Thank you! And oh, btw, I take 100 mg., maybe that's why it's taking longer to drop my cancer antigens, but they ARE going the right direction, that's what matters! You are so welcome! <3
That is great news. So glad this protocol is working for you. Also it is interesting that Letrozole caused high blood pressure. Mine has definitely been higher since I have been on this and I was already on blood pressure meds for many years. It is very high at the oncologists office.
I have a sneaking suspicion that until Pfizer comes out and says it's ok, even preferred, they cannot endorse any change to protocol without being open to lawsuits? maybe? something .... Pfizer should be coming out with it soon as an approved protocol because afterall, they are in the business to make money and the best treatment options keep the patients healthier and makes them live longer thus taking the drug longer.
You know at the end of the day it's all about His will for my life, I just praise God for all He's done for me, leading me, guiding me ... I know I'm not that smart LOL
I was diagnosed mBC this past January w mets to lung and bones. I started 125 mg Ibrance on std protocol - 3 weeks on, one week off, and daily letrozole, and monthly xgeva. My tumor markers started coming down immediately and at my last appointment, 8 months into treatment, my CA-125, which was at 200 less than a year ago, was in normal range of 35. My scans are showing No Evidence of Active Disease. Although I don't feel any side effects from the Ibrance, my white counts have been gradually dropping. My doc kept me off Ibrance for an extra week and my white counts went up. But instead of going back to the old protocol or dropping my dose on the old protocol, she has recommended I stay on the 125 Ibrance but take it every other day. This means less medication overall (14 pills in 4 weeks instead of 21 pills), but should help me keep my white count up. I think the rationale is that if the meds are working that well, you shouldn't have to continue to medicate so intensely. This might even allow me to be on the meds longer overall. I trust my docs (at Sloan Kettering) to prescribe the meds according to the patient's specific disease and to know me. My doc also moved my xgeva injections to once every 6 months, which I am glad about, because monthly is so much for a med that has a six-month half-life and can have so many side effects. Everyone's different -- know yourself, know your doc, and make sure your doc knows you and is thinking about your long-term survival!
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And oh, btw, I take 100 mg., maybe that's why it's taking longer to drop my cancer antigens, but they ARE going the right direction, that's what matters! You are so welcome! <3
ibrance 5 days on 2 days off?
ibrance schedule 
Ibrance schedule 
Alternative to Ibrance (palbociclib)
Weekly schedule of 5 days on, and two days off CDK4/6 inhibitors
