what is you ki67? Are you lobular or ductal? How are you doing? My ki67 is 15%

[DDIL1]

Just wondering what others have for a ki67 and how you’re doing? I’m ER/PR+ Her- Mets to bones now colon. Wondering how others are doing?

[Kahe]

Hi Ddil, I am also interested in replies to your post. My ki 67 is 34% and I am told anything over 20% is considered aggressive. I would like to hear what others have to say about this

I am ducal, several mets to right lung, being treated with letrozole, palbo 125 mg and faslo for past year. Stable, scans showing some tumours gone, others reduced. Overall I am doing well, working, exercising, only side effect fatigue (fingers crossed). Hope you are also managing well 🙏

[ba5083]

I have ILC , ER/PR+, HER2-, Ki-67 12% on left and 8% on right, OncoType result 14. Diagnosed 4/28/22. Currently on Exemestane will be starting Verzenio within the next month. Was on Ibrance and Letrazole with no luck.

[Tolife_18]

You raised a very interesting question. My oncologist (US, MSKCC) doesn’t order this marker.

Is it standard for MBC?

How often it’s performed?

Thank you

[TammyCross in reply to Tolife_18]

My Ki-67 was reported in the biopsy of the large tumor I had when first diagnosed with mbc. Mine was 25%. Funny -- I remembered it as being much lower. Here is what the report said:

Ki-67(MIB-1) % tumor cells positive: 25% No current consensus exists as to the methodological evaluation, optimal cut off and algorithm of clinical usage of the Ki67 labeling index. Proposed cutoffs noted in the literature vary from Unfavorable >10% or >14% or >20% or 30% (St.Gallen). Intermediate 10-14%, 10-20%, 16-30% (St. Gallen).

So, I could either be unfavorable or intermediate. Not great! Yet I have been told my cancer is indolent, not aggressive. I have been doing very well in some respects -- two periods of NEAD in four years, and feeling pretty good until now. I am on my third line of treatment, however: my cancer seems to be very responsive but develops resistance too quickly. Now I am feeling lousy. We don't know if the cancer has progressed or if this incapacitating fatigue and malaise is a side effect. I have been having bad side effects from anastrozole (letrozole was worse, so I switched). Also on lowest dose of Verzenio, which is contributing. Having a scan next Saturday and dreading, dreading the outcome. Because I have felt so well, so healthy, most of the last four years, I have been able to imagine I will have a long run of being functional and overall health. Denial, I guess. Trying to face up to what may be bad news. Perhaps on to the next (4th!) treatment. My oncologist has been trying to find a clinical trial for me, but no luck.

I meant to put this into a separate thread called something like, "Need to whine"

[Tolife_18]

thank you so much for your reply. Wishing you good results on your scan!