Inbrance schedule

[Archiedog]

Hi , just wondering do any of you have a 3 week on 2 week off ibrancr schedule, I’m on 75mg and have had 24 cycles. Only effect is neuts are regularly low. I have pushed for this schedule , my oncologist doesn’t seem too alarmed just wondering if this is a recognised treatment pattern. I am currently Ned and take letrozole. Any response would be helpful

[Nocillo]

Yes, I’ve been on 3 on 2 off for about 18 months now. It’s working for me.

[8576]

I am not on Ibrance. I am on Verzenio which is a sister drug to Ibrance. You will find plenty of answers to our question if you do a search of this site.I am doing alright on this but have taken the summer off from scans because I was feeling well and wanted to enjoy the good weather.

Cheers, June S.

[Dragonfly2]

Hello! Very glad that this 5 week schedule is working for you…as long as you c@n tolerate those low neutrophils. What is most important is that you continue to talk to your Onc and stay aware of how you feel. It’s a marathon…and you need to stay strong for the long haul . Best wishes!

[love2golfwell]

So happy that schedule is working for you, especially being on the lowest dose of Ibrance. I have always been on the 3 weeks on, 1 week off and am on 125 mg. I have not had really low neutrophils on this schedule and hope for it to stay that way. I will be on this regime for two years this coming November and so far, so good. Hope you continue to have good results.

[Threadsgirl]

I switched to a 3 week on 2 week off schedule for Ibrance 125 mg after I had about 3 months where my neutrophils did not recover enough in one week to restart it. Have been on this schedule about 6 months, on Ibrance for two years . Last scan was clear. Feel better too.Also take Letrozole. My oncologist was fine with it but strangely I had to suggest it. Maybe they want the patient to request switching the schedule do they are not on the hook if something doesn’t go right. 🤣

[Totheriver]

I am on 75 mg of Ibrance. I do two weeks on two weeks off. This is the only schedule I could tolerate.

[Shar313 in reply to Totheriver]

Same here. I have been on the 2/2 for about 3 years. My neutrophils are around 1.1.

[Totheriver in reply to Shar313]

My neutrophils are between .9-1.2. I have done this for close to two years. Tried many other combos first. I have had mbc for 31/2 years.

[BlessedMimi]

I have been on the 3 week on and 1 week off schedule for 2 years. Now I am doing 75 mgs. Usually have to do an extra week off because of the low neutrophils. Last month I was switched to 2 weeks on and 2 weeks off and my levels were better. Not sure if I am comfortable with that, but will do it until the next scan to see how that schedule is working.

[mariootsi]

I am also 3 weeks on 2 weeks off. Taking Ibrance 100mg. My platelets go low!

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[ba5083]

Here is an interesting thread started by DragonFly2 a couple days ago. Could be another option to discuss with your Oncologist - healthunlocked.com/share-me...

[Hotlantaphatz]

I am 3/1 on ibrance for one year. Low neutrophils.

[Hidden]

Dear Archiedog,

How are you? I have a question. Does that mean that when you are NED you stop Ibrance?

Thnaks for your help

[Archiedog in reply to Hidden]

Hi, I’m very well thank you, I think , I feel well but had my 3 monthly scan on Friday so am now in limbo waiting for the results which I was told will take up to 11 weeks 😳. I still take ibrance and letrozole and am hoping this combo continues to keep keep me stable for a very long time to come xx