Does anyone have experience of injections of the above combined with letrozole please and how did you cope with them?
Denusimab: Does anyone have experience... - SHARE Metastatic ...
Denusimab
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I started Denosumab in April 2021 when I had my chemo. Had no side effects. I started Letrozole (along with palbociclib) in October 2021. I get lots of aches and stiffness in joints from the Letrozole.
I’ve been on both for almost three years with Ibrance. I never noticed any side effects. Two months ago my doctor switched Ibrance out for Verzenio, still no side effects. I hope you do well and have a long run on your protocol! Best wishes!
We are so individual! Denosumab is Xgeva. I got bad eczema from it, and then I got osteonecrosis of the jaw, a supposedly rare adverse effect that some of us on this board have suffered and have given graphic descriptions. But then, I had trouble with Letrozole -- the aching hips, and other effects -- so switched to Anastrazole, no side effects. FierceFighter says above that she has no side effects with Verzenio. I did and had to stop and will be going on a reduced dose. I had no trouble with Ibrance, except for hair thinning. Others do -- so you just have to see if you are in the majority that does well with Xgeva.
When they are that bad, they are "adverse effects." I lost quite a few teeth. I am okay but it is not good to lose 4 molars.
Denosumab is a quick small injection into the subterraneous fat in your tummy and generally easily tolerated. I have found it so much easier than Zometa which required a visit to the chemo suite and an IV drip into the back of my hand which became more and more sensitive. On Letrozole I had aching joints etc. but I moved from Letrozole on to another treatment at the same time I moved on to Denosumab so I didn’t have both treatments together. Both meds should be fine but will you have Letrozole with another treatment alongside it, which is normally the case?
I am only a month into treatment with Letrozole and my oncologist told me about the Denosumab injections. I am having another scan in six weeks' time to measure progress so I shan't know until then if anything else will be added. Thanks for your message; it is very encouraging
The Denosumab is for your bones. I started on this before Letrozole and Ibrance (palbo) and found my back pain lessened immediately.I do my own injection at home which saves a trip to the hospital.
Hope it all goes well for you
Clare
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Thanks, Clare, for your cheering reply. You are very brave to do your own injection though the travel to the hospital is a bit of a pain. Well done
It’s actually easier and less of a shock doing it yourself.I have been going to the hospital monthly for 3 years, and wait hours for a quick injection, so I am chuffed I don’t need to go there any more.
Hope you continue for a long time on these meds
Clare
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Thanks Clare. I don't know why but sticking a needle into the fat of your tum sounds less scary than into your arm. I think the latter is a more painful area.