Anyone on the MORPHEUS-2 trial or any other trial with Giredestrant?

My onc wants me to consider screening for the MORPHEUS -2 trial (Genentech). Anyone else on this trial or an any other trials for the Genentech oral SERD giredestrant? Would be interested in hearing about any side effects.

[friesianfan]

Hi there! I don’t remember reading about anyone on this particular trial but hope there might be someone out there who can help. I do know that there are a number of ladies who have had good luck with some of the other oral SERDs, which seem to be a very promising family of treatments. My wife just spent 13 months on a Phase 2 trial for Amcenestrant, the Sanofi SERD that looks very promising. She did have some progression late last fall so has switched to Xeloda. In terms of side effects, the SERD was the best so far compared to 3.5 years on Ibrance and her first few cycles of Xeloda. Very positive QOL, Hope the same for you, if you do join the trial! Good luck!Dave

[Hidden in reply to friesianfan]

Dave, thanks for your response. Glad to hear that your wife did well on the oral SERD. I hope that Xeloda continues to work for her. Liz

[Fifilatour]

Hi! I found out today I am eligible for phase 3 and will know more next week. Just found out Ibrance/fulvestrant not working - only got 3 months of good results. Now at month six turns out the mets in my liver are growing again and I have 14 small lesions in my brain. So onto the next treatment. Looks like my onc is leaning toward Genentech Morpheus for me. I will keep you posted if I end up in it. Should know in a few days. Hope you are doing well! Liz

[Hidden in reply to Fifilatour]

Hi! I have enrolled in the Morpheus-2 study and I’ve been randomized to the Giredestrant + ribociclib treatment arm. I’ve been taking the meds for three weeks now and there’s no bad side effects so far. Just slight nausea with an hour of taking the drugs but that disappears after 1-2 hours. I’m also trying some additional meds to control it. I have bone Mets which progressed to the liver after 11 months on Ibrance and Arimidex. Please PM me if you have any questions or need any additional information. Where are you being treated?

Liz

[Fifilatour]

Hi UKCAGirl - I’m at Stanford. Good luck on the trial! Thank you for the update. I will keep you posted…

[Pbsoup]

This is interesting,

I wanted to go on a trial for an oral SERD when I progressed after Ibrance but my Onc says Xeloda is working so we should wait.

You sound like you're all in the bay area--I'm in Sonoma but my doctor is in SF. I was looking at trials at UCLA (my daughter is in LA for university so I thought I could visit when I went down) But it's interesting there is one at Stanford! UKCAGirl where are you?

[Hidden in reply to Pbsoup]

Hi, we have messaged in the past about theses trials. The MORHEUS 2 trial is recruiting at Stanford and UCSF. It’s a complicated trial design and not all treatment arms are available at both institutions. The intended population for which they are seeking drug approval is patients who have failed first line therapy but not started second line standard of care therapy. I had the opportunity to enroll in the study or do second line stand of care (probably Xeloda and Faslodex for me). I selected the study as moving straight to the second line SOC would have made me ineligible for many of the oral SERD studies later. Also I can still do second line therapy if the trial doesn’t work.

I enrolled at UCSF as I was already in discussions with your favorite oncologist (!) about a different study had my Ibrance/Arimidex continued to work for longer. After I had progression to the liver in Jan, UCSF recommended MORPHEUS 2.

There are numerous (10 or more) clinical studies on oral SERDS at the moment. You may want to look and see if you fit the inclusion/exclusion criteria now that you have used Xeloda. If you want more info, please message me.

Glad to hear that you’re doing well. I’m based in the Bay Area.

Liz

[Pbsoup in reply to Hidden]

Oops. Sorry. I’m being dim. Of course we talked about this. 🤦‍♀️

Thanks for being patient with my brain blip!

The whole study thing is somewhat opaque to me. It’s a reason I sometimes regret leaving UCSF.

Onward!