have anyone taken part in the serena 6 trial and can tell me how they got on

[Sharonpat]

I have stage 4 metastatic breast cancer (liver and bones) iv done 6 cycles of Ec chemotherapy and I’m due to start letrazole and abmeciclib on April 21st

Does anyone here have this and how did you find it

My bones have all healed and iv been told I’m stable re my cancer

After 6 months I have been offered the serena 6 trial has anyone else heard of this or been offered it please

[GollyG]

Hi there, I was on this trial last year at the Marsden in London. I was convinced that I was taking the SERD as I felt sick quite a bit but then I got more liver progression and when they unblinded it, turns out I was on the placebo, and gallstones probable cause of sickness. All the blood tests did reveal the pic gene so now I'm doing well on Piqray.Good luck - hope you get the actual drug! Gill

[Sharonpat in reply to GollyG]

oh gosh that’s not so good I hope I get the real drug then it won’t be for another 6 months what is picray xx

[GollyG in reply to Sharonpat]

I can't remember it's other name - alpesilib or something - but it's pretty new to the UK and targets the mutation they found, which is good x

[MyMiracle13 in reply to GollyG]

Hi. What side effects are you experiencing on Piqray? Are you taking it with Fulvestrant injections? I will be starting on Piqray in a couple of weeks so any info you can share will be greatly appreciated.

[GollyG in reply to MyMiracle13]

Hi, yes with Fulvestrant. My hands and feet are dry but Eucerin over the counter cream keeps them soft. My stomach is unpredictable but it might be the gallstones - I get occasional diarrhea. Otherwise, pretty good! And it's working. Good luck with it.

[MyMiracle13 in reply to GollyG]

thank you for replying so quickly. May I ask if your blood sugar is going up? I believe that a major side effect of Piqray is that it may lead to type 2 diabetes.

[GollyG in reply to MyMiracle13]

Yes, blood sugar did go up. I was already taking Metformin as prescribed by COC and they increased my dose which has kept glucose under control.

[MyMiracle13 in reply to GollyG]

Thank you. I have trouble swallowing big pills and the metformin here is huge. I’m looking into pediatric oral solution metformin.

[GollyG in reply to MyMiracle13]

You're right, they're huge here too! An oral solution sounds like a smart option 👍

[Sharonpat]

aww that’s good to hear I hope I don’t get many side effects wishing you good luck