Only 6 months on 1st line treatment

[peggylz]

Well I just had my latest scan come back and there is a new area in my liver measuring 2.5cm x 2.5cm. My oncologist from BJC is very concerned. She ordered a genetic blood test to see if the original diagnosis has changed form from ER+ HER- . After results we will decide what next line of treatment should be. I do have Mets pretty much throughout my body. Anyone have this happen and what was 2nd line in such a short time

[Missmaddie615]

I got positive results for only 6 months on Ibrance, but I stayed on it for a year. After the 1st 6 months, it stopped working and by my 9th month I had progression. A little background....My mets were found by the Grace of God. I was having my gallbladder taken out in June 2020. My surgeon saw something on my liver. He cut a piece of it, (wedge resection), and sent it out to pathology. It came back that it was my breast cancer that had spread to the liver. So after a battery of scans,(brain MRI, CT scan, abdominal MRI and bone scan), nothing was found, not even in the liver. I then had a PET/CT scan and it showed that I had cancer in the sternum and some lymph nodes, still nothing in the liver. Why it never showed on the CT or bone scan is still a mystery. I was put on Ibrance/Faslodex and for 6 months all was good. My scan this past April was not good- sternum lesion had grown, etc., but still nothing in the liver. I continued on Ibrance/Faslodex for three more months and my July scan showed my sternum lesion had grown even more and now progression in a different area of my liver.

Last year my oncologist had sent my wedge resection of the liver to Tempus labs for testing. It was found that I have a high tumor mutational burden and PDL-1. Because of this, I am now on Keytruda/Abraxane as my second line of treatment. My oncologist has also talked about Piqray (I have the PIK3CA mutation), and Xeloda for me, so I know those will be in my hopefully far, far, far distant future.

Having progression and changing treatments is so scary, but there are so, so many treatments out there. Please don’t be discouraged -be kind and gentle to yourself at this time. May the Lord guide and direct your oncologist to the best treatment for you and may that treatment be manageable and give you positive results for a very, very long time! 🙏❤️🙏