Line of treatment

[marianne88]

Hi. Just wondering how long ibrance and faslodex worked for you? What was your next line of treatment. Thanks.

[ndastrogal]

I also would like to hear other's experience. I've been on both since Nov 2019 and having my scan Feb 17. I tolerate it very well but always think it's not working!

[marianne88 in reply to ndastrogal]

Why do you think it’s not working?

[ndastrogal in reply to marianne88]

Because I have zero side effects and sometimes think I should be feeling something. But I also know I should be grateful for feeling good. Scan will tell all.

[marianne88 in reply to ndastrogal]

Why do you think it’s not working?

[Susan1953]

Ibrance/letrozole, 33 months

[Selmac]

Hi Marianne, Ibrance and Faslodex did not work for me at all. I was on it six months and had progression. Since then, I have been on Afinitor and Aromasin. Over 2 years with no progression.

[Wintervt in reply to Selmac]

Sorry to high-jack the post but this is good to hear. I am currently on Falsodex after 18 months on Ibrance/Letrozole. My tumor markers are going up and I'm scared, hearing your success gives me hope.

[marianne88 in reply to Wintervt]

What are your tumor markers at

[Wintervt in reply to marianne88]

My CA 27-29 is at 240

[marianne88 in reply to Wintervt]

What is your CA 15-3

[Chrissie-Mac12 in reply to Wintervt]

Are you on Faslodex alone?

[Wintervt in reply to Chrissie-Mac12]

Yes, Faslodex only, pending the results of my liquid biopsy. If I have the P13K mutation she will add Piqray.

[Chrissie-Mac12 in reply to Wintervt]

That’s a great response. Ibrance and Letrozole failed me after 16 months. I’m starting a trial on Wednesday where I will either get Faslodex alone Or Faslodex with a leukaemia drug called Venetoclax. It’s good to know that you’ve had a good response to the singular treatment. I’m in Australia

[Wintervt in reply to Chrissie-Mac12]

Will you know which arm of the trial you will be in? I just met with my oncologist at Dana Farber in Boston and she did not mention the trial you are participating in. Hoping you have great results!

[Chrissie-Mac12 in reply to Wintervt]

I find out tomorrow. It’s called the Veronica Trial. It’s currently a phase 2 trial with 100 participants

[Wintervt in reply to Chrissie-Mac12]

Keep me in the loop! xo Jade

[Wintervt]

My oncologist only does 27-29

[Wintervt]

It has increased from 80 to 240 in two months.

[marianne88 in reply to Wintervt]

Oh my dr only does the 15-3.

[Wintervt in reply to marianne88]

It's interesting what oncologists rely on.

[PJBinMI]

I got over 9 years from Faslodex, second line treatment after nearly 5 years on Letrozole. Drugs like ibrance were not around when I was diagnosed in 2004. I did take Ibrance for a few cycles in 2016 along with the Faslodex, but it damaged my lungs. I've been on Exemestane for a bit over 2 years, now . But we each have our own set of cancer cells and how we respond to treatment sure varies What I suggest for all of us is getting a second opinion from an onc who specializes in breast cancer. The top cancer centers in the US are those called Comprehensive Cancer Centers and they are listed under "resources" on the right side of this group' s home page. The CCCs have very specialized oncs who both see patients and see patients. They are great for second opinions.

[Evbr in reply to PJBinMI]

Hi, what do you mean by “damage my lungs”? What happened?

Thanks

[PJBinMI in reply to Evbr]

I developed a condition called"Interstitial Lung Disease," which Ibrance can cause. The pulmonologist described it as being like "gunk" between the air sacs. It causes getting out of breath easily.. And it led to me also developing atrial fibrillation. So now I have two more doctors and 3 more meds plus compression sox. ILD is supposedly a "rare" side effect of Ibrance, but when I started on it, the drug company did not have the warning about it that is has to have now. I get out of breath just getting showered and dressed in the morning.

[Gwennie123]

I was on Ibrance, Faslodex and Xgeva for14 months. They stopped working and now on Doxil and Xgeva for 2 months. Manageable side effects. Fatigue and headaches.

Hopeful.

[8576]

Sorry, can't help you there. I am in the process of getting started on Faslodex and Ibrance. Not sure I will proceed the cost is prohibitive. Faslodex is $832.00 per month for me. Not covered by government health plan. Seems to be a good combo, judging by posts here.

Cheers, June S.

[Lordmandy]

Ibrance and Femara from 4 years and 4 months. In Fulvestrsnt only for now, while finishing radiation, because of risk to bone marrow during radiation. The plan is to begin Ibrance again, with the Fulvestrant 3 days after radiation because it has been do effective thus far. I am requesting to go to Kisqali instead, another CDK 4/6 inhibitor instead because studies have shown it to work longer. Not sure if doc will allow. I just learned that I am pic3ca positive, which makes me eligible for the new drug, Piqray, Which targets that specific mutation; but I understand the side effects are more difficult, so I want to continue CDK 4/6 inhibitor first. there are clinical trials underway now that Are showing CDK46 inhibitors may begin working again after a seven week vacation because of the way the sales communicate through genomes, And not replicating mutations. As it turns out, after fighting insurance to cover my treatment, and then the treatment itself, I will have been off I Brandts for seven weeks. I am expecting it or Kisqali will work again.

[Lordmandy]

Please excuse typos.

[hdhonda]

Marianne, I am on my 35th month of Letrozole/Ibrance combo. My next scan is in March. Blessings, Hannah

[Have-faith]

Faslodex worked for about 5 months on me. Next line of treatment became

afinitor and exemestane which has had very good results for me. Markets went down to 27 u til this month when they popped up to 34. I have had pneumonia since October so this maybe effecting markers. Pneumonia is almost over, but it takes months sometimes to get back up to speed.

[Epinto]

Hi marianne88. I have been on ibrance 125mg. And faslodex for almost four years this coming may. Always realistic that things could change but grateful so far! Hope u r doing well.

[jstickrod]

It worked for 18 months for me, then had to switch due to many infections. Switched to Xeloda, and have very few side effects. Been on Xeloda since April 2019

[Stinsonmom]

It worked for me for nine months.

[SeattleMom]

Hi, Marianne,

I have been treated since diagnosis of MBC with the combo Letrozole and Ibrance (100 mg) for the past 26 months.

Linda

[Jeremiah2911]

Hi Marianne,

I have been on Ibrance/Faslodex for 14 months now with tumor markers dropping & tumor shrinking. I did 125mg dosage for a year but fatigue was getting to me so we switched to 100mg last two months and it’s really helped. So hopeful to hear others have been on this combo for years! Prayers for us all 🙏🏻❤️

[Klamato]

Ibrance worked by containing my Mets for 19 months. My new medication is Verzenio 100 Mg. Along with Tamoxifen . This was decided by two major cancer centers and the respective docs. Just hoping it does the job before I would go on chemo. Keeping my fingers crossed,❤️👍 Kathy