Balance Issue? Palbociclib / Letrozole

[Hihif]

Is anyone having any balance issues?

[Burgerde]

I definitely have balance issues and am on two drugs which are in same category. I believe my issues are due to the total brain radiation I had due to brain mets but does seem worse now when you bring it up.

[Hihif in reply to Burgerde]

I thought that my balance issues were from chemo and radiation but I had to go off Palbociclib to take antibiotics for two weeks and my balance improved dramatically. I can walk without falling. I never noticed that my neuropathy got worse in my right foot and hands because of the fatigue.

Curious if any one else has balance issues?

Are the balance issues only with survivors who have brain Mets?

[Hidden in reply to Hihif]

I wonder too. I had some neuropathy in fingers and toes after chemo and radiation in 2009, more balance issues since 2014 on faslodex and xgeva. Since Starting ibrance and leterzole in May and having radiation on new tumors, my balance has been awful. It did seem better when on my off week. I was driving and using a cane occasionly. Now it's walker in house and a cane at all times. No driving either. Others with changes in neuropathy since ibrance.? Thanks for bringing up the question Hi.

[Hihif in reply to Hidden]

Hi Jaxn,

Do you have or have you had any tumors in your brain or spine?

The reason I ask is that I’ve seen a couple of posts on another website with Palbociclib and balance but they had Mets to brain and/or spine.

Texas Princess

[Hidden in reply to Hihif]

Tumor on my spinal cord in 2014. May I ask what other website? I didn't mention fingers worse and hands shake too. Thanks

[Hihif in reply to Hidden]

I’m so sorry. Praying for you! 💕💕

I also developed neurapathy in my hands and have been unable to use my thumb with index finger. It disappeared after stopping Imbrance for two weeks.

I hope this information helps you.

I googled Palbociclib neuropathy and multiple sites came up. One of them was Team Inspire for Group discussions, titled Sudden Severe Neurapathy while on Imbrance.

[Hidden in reply to Hihif]

Thank you I will check out. I am end week one cycle 3. Hope it doesn't get too much worse. Best to you.

[Hihif in reply to Burgerde]

Thanks, Burgerde!😊💕👍

[blms]

Very interesting!!!

[Kakoburr]

Hi this is Karen. Balance issues can be caused by many things but please run it by your doc: s/he may want you to get an MRI. Not to worry you, but sometimes, as in my case, it can be an indication of a metastasis that is most readily addressed early. For me signs were some balance issues and suddenly more errors typing. Am still clear 2 years after surgery to remove tumors and subsequent radiation.

[Hihif in reply to Kakoburr]

Hi Karen,

Thank you for your advise. I’ve had 3 MRI’s in the last year and I’m on a watch. I’m getting a spinal tap on Friday. I have a couple of lesions growing. One is 2cm. I’ve also developed mild white matter disease after chemo ended. I was working with a neurologist but have just learned I need to work with my oncologist and primary physician.

Thank you for sharing! 🌹

[Kakoburr in reply to Hihif]

Thanks to you too, Hihif! In my experience, it was the lesions, not the meds. Once taken care of, issues with balance and coordination went away.

[charlie1712]

Yes. I’m on Ibrance 125 mg 21 days on/7 days off on a 29 day cycle. Some days my balance is affected; some days not. Had to reduce dosage to 125 mg 15 days on/ 14 days off to raise my neutrophils. I recovered somewhat and was put back on regular dosage. Re: balance-some days light headed and some days it’s worse . I’m 1-1/2 years with the Ibrance and fatigue is always present to some degree. Minor bone aches but not regular.

[charlie1712]

Sorry. Correction: 28-day cycle and 14/14 on/0ff reduced schedule. And I have bone Mets but very stable last couple of scans.

[Hihif in reply to charlie1712]

Thank you for letting me know I’m not alone. Stay strong!😀

[nstonerocks]

Yes. It isn’t dramatic but I do notice I have some trouble. I thoughts it was old age or being out of shape.

[Hihif in reply to nstonerocks]

Me too! Stay strong! It looks like it’s may be fatigue/ neurapathy!🤔

[Garnet131]

This is interesting because now that I've been able to get back to tap dancing, I've noticed that my balance is terrible. I don't notice it much otherwise, but it's definitely bad at tap class compared to what it used to be. Hadn't thought of it being the Ibrance (just finishing 10th cycle).

[Hihif]

Glad to hear you are Tap dancing! 💃

I think one of the side effects is mild neurapathy that we don’t notice until we are more active.

It’s a good thing to watch from a safety standpoint.

[PJBinMI]

Balance issues the kind of thing to report to your onc today! We all need to know how best to get messages to our oncs--often by phoning their office and talking with the nurse or assistant who works closely with our onc--and some things need to reported today, some need to be reported at 2 am on Saturday morning, and some need us to go to the ER right this second. Talk with your onc about what needs immediate reporting and what can wait!