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Ibrance intestine issues, anyone got that too?

I just finished my second cycle of ibrance 125mg. My major side effects is intestinal issues. I get severe pains or aches or cramps, I actually do not know what to call it. I get fatigue but the pain in my stomach supersedes every other side effects. I also have insomnia, upper and lower back pain.

Anyone seen such side effects?

I'm thinking of telling my doctor to lower my dose. I'm afraid it could be causing more harm than good in my internal organs.

Recently I take maximum strength liquid antacid, it helps sometimes but makes me have diarrhea all day long which is actually better than the pain.

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A Ibrance side effect is diarrhea. I usually have to take a few immodiums during my cycle. I sometimes have that pain also but when it go to the bathroom it feels a lot better. I'

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Sorry I hit the enter key by accident. When i started Ibrance my prescription co. Made me speak with a specialty Oncology nurse who strictly talks to Ibrance users. I take Nexium for acid reduction. She told me that acid reducers interfere with Ibrance. I have to take the Nexium at least 5 hours earlier than Ibrance, also to take Ibrance with a good meal. This probably isn't an answer but just wanted to share.

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Thanks, i wish i can talk to the nurse too. I also take nexium 24hrs. I was taking prilosec. But I usually take them before breakfast and take ibrance with my dinner around 7pm. Yes ibrance causes diarrhea which helps me feel better from the gas, but not enough. I take mylanta like water cos the stomach is killing me.

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Hi Swtberry,

I just completed my first week of Ibrance and am wondering if the gas I am having is related to the Ibrance? Is that what is causing you pain? I am so use to having diarrhea when I was on Afinitor I am wondering if the change is meds is causing my constipation and gas? I also didn't see anything in the materials that were given to me that Prilosec would interfer but I take mine in the morning and Ibrance at night with yogurt or some other small item. No nausea so far...

Mary

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Hi Mary,

Yes gas the doctor said is the ibrance, even during the 7 days off, the pain gets worse. She said it's the accumulation of ibrance. I have kind of loose stool with ibrance, though not bad.

The pain is so bad for me. Thinking I might step down on the dose.

Started my 3rd cycle today.

Good luck with your treatment

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You can try a probiotic and see if it helps.

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Thanks I did try that but I have been off I ibrance since April. Been on traditional iv chemo.

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When I began Ibrance I had a ton of nausea and I was constipated. It took a couple of months for the side effects to go away. I do take Vimovo for bone pain and it has a built in stomach pill that may be helping hide some of my stomach issues. My biggest side effect is my neutrophils dropping extremely low. My Dr had to lower my dose to try and improve my neutrophils.

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Thanks, I have been off ibrance since April. Been on traditional IV chemo since then. Thanks for your advice. Pray we all feel better soon. Good luck with your treatment dear.

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I've been living with bone mets from the get go and an E + ILBC that has responded very well to hormonal treatment for over 14 and a half years. My impression is that the newer drugs prescribed with hormonals, specifically Ibrance and Afinitor, are given way too much credit and that their potential side effects are not discussed enough. I am biased by my own experience with Ibrance, which I took for almost ten cycles in 2016, I have been off of it for two years now but still have damaged lungs that my oncs, my pulmonologist and I all think was caused by the Ibrance. I have something called Interstitial Lung Disease (ILD) which I was told is like gunk between the air sacs. I get short of breath very easily, sometimes just leaning over to tie my shoes and that can take 5-10 minutes to recover from. A dear friend died from pulmonary effects of Afinitor shortly after it was FDA approved when her doctors did not put two and two together and kept her on Afinitor even while she was in ICU for acute pulmonary collapse. So my bias says "DO NOT WAIT TO TELL YOUR ONC ABOUT LUNG ISSUES WHILE ON THESE DRUGS." As in phone them on Saturday night at 2 am if you have trouble breathing, or go to the ER. It's better to act a bit too soon than not soon enough. I don't know if there is a way for us to get info from the FDA or the drug company about how many serious side effects of a specific kind have been reported for these drugs. My onc recently retired and I have a new younger onc and have told him how reluctant I am to even consider Afinitor...... he is not pushing it!

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Thank you for the heads up, this is important information. Of course our oncologists don’t tell us this. I don’t even know if any of them really know, as ibrance is new. Your story always gives me hope, I really enjoy hearing from you. Any information from all the women that have lived with mbc for so many years is always appreciated, believe me. Have a great day.

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That's for the heads up. I started afinitor and exemestane 4 days ago. I have to watch out. I'm having flu like symptoms, stuffy nose and some effects I cannot describe already.

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