Can anyone explain how slow release works for them? I recently asked my g.p. for this and was prescribed one 260 microgram at night. Previously I was on normal pramipexole for several years, latest dose being 2 x 180 microgram tablets per day, taken around 7 pm and 2 am. However the slow release, taken at 7 pm, left me without any relief during the evening or night. When is the best time to take it for relief during this period?