what is the highest dose of Mirapexin for RLS.

i am taking the prologed release type of Mirapexin, currently taking, 1.05 mg, and i want to know what you think is the highest i can go to. thank you.

jean

[birdman74]

Niah

I'm interested in the fact that you are taking 1.05mg Mirapexin - I assume that you take this at one go and at a specific time of day. I am taking a 0.18mg tablet in the morning and a 0.35mg tablet in the evening. I also have a 3.0mg Neupro patch. I intend to ask my consultant if I can up the dose of Mirapexin when I next see him. I do occasionally slip in another tablet if I am having a particularly bad night but that does not appear to have any affect on my legs or give my any adverse side affects. I will look with interest for any other answers to your posted question.

[Hidden]

Hi birdman, thanks for answering, im hoping one of the medical proffesion who look on here will answer this for me also, as far as i can gather, i dont know anyone else who takes the prolonged release type of this med,(Mirapexin) so i cant judge the difference in reaction to it. I take one pill at night, around an hour before bedtime, and it usually works well, but i have Menieres Disease, and when i get an attack of that, it seems to send my legs crazy, not nice, extreme vertigo, nausea, and my legs kicking of. I was taking Gabapentin,but i gradually stopped, i wasnt helping the RLS,but was good for the pain from Sciatica, and as i have Codydramol, i couldnt see the point. I used to use the Neupro patch, went right up to 8mgs, i knew that was to high, but my doctor said use it, so, what do you do,!!. well heres hoping for another answer, as trying to get an appointment with my GP, is like asking for the moon. hope you have a good day today Birdman.

jean

[birdman74 in reply to Hidden]

Jean

Thanks for your reply. I don't know anything about the prolonged release type of Mirapexine so can't help any further on that count. I was interested in the fact that you had been up to 8mgs on the Neupro patch - that seems excessive but gives me scope for an increase from the 3mg that I am presently on. I certainly have to investigate a different regime of medication as what I am on now is neither giving me good nights plus I have the symptoms of RLS from late morning through to going to bed.

I sympathise with you regarding the Meniere’s disease as my Wife Val has it. She is in remission at the moment but has had to endure two major operations on her inner ear (saccus decompression) carried out at Addenbrook Hospital in Cambridge.

Have a good night

[Hidden]

Hi Birdman, thanks for your answer, as for the 8mg patch, it was way to much, more than reccomended for us, but we cant argue with the doctors can we. I did have a permanent chronic headache, so the doctor agreed to give me the Mirapexin, i didnt know about the prolonged release, untill i picked it up of the chemist. As for the operation for Menieres, they offered my one but i cant bring myself to go through it.

jean

[birdman74 in reply to Hidden]

Jean

I don't know about arguing with the doctors - I appear to be educating my doctor on both RLS and the medications prescribed for the condition. I have suggested the medications to him and he then looks them up in his reference books and either agrees or disagrees. For the patches however I had to see a specialist and it was he who agreed to the use of the patches and then, when they did not work, to augment the patches with the Mirapexine that I was already taking. I am planning another visit to the specialist to discuss a new or revised regime of medication as the symptoms are worsening.

[drew410]

I was prescibed the lowest dose of mirapexin (0.088mg) for RLS with directions to incresase to 2 after one week. Worked perfectly. After being unable to sleep for 7 months at night I slept through after the second night of 2 tabs. I was then, after 1 month, put onto CR 0.25. My dyskinesia and dystonia went off the scale (sorry should have said, I have Parkinson's). Took me over 10 days to balance my mirapexin. Now back and settled on 2 x 0.088mg and sleeping again normally.

[Hidden]

good morning all, Drew you didnt say if you take the prolonged release version of mirapexin, this is the one im having trouble checking, the normal one, i can find out about, but its just this one, i need to know about, but i appriciate you reply, thanks,,,,,, Birdman, when i first asked my doctor about treatment for RLS,he was fine, we worked through things together, and learned about the meds together, but, since he sent me to see a neurologist, pfff, between then they are allways trying to get me on antidepressants, and i nearly gave in to their pressure about 2 months ago, they had me convinced !!! im not depressed, i get a bit down, as everyone does if they havent slept, they are convinced that depression causes RLS,! and i dont think it does, lack of sleep is my problem, and if we have the right meds to help control RLS then we sleep. Apart from that situation with my doctor, they have a system at my surgery, you ring for an appointment, they give you a time when a doctor will ring you back at home, they talk to you and decide if they think you need an appointment, we are NOT allowed to walk into the practice to book an appointment, its by phone ONLY, and if the doctor says he wants to see you, then you get an appointment, and there is no way around it,

jean

[Hidden in reply to Hidden]

Jean, WE know that depression does not cause RLS, its the other way round, we can all get drepressed when our lives are disrupted from sleep deprivation. Some people DO need a anti-d when things get really bad. Seems some doctors STILL need educating on what DOES cause RLS, or for the most why people get depressed when they have RLS..

Sorry you havent got the answer you are looking for yet, on your prolonged Mirapexin... Hope someone lets you know soon...

Irene...

[drew410 in reply to Hidden]

Hi Jean, NOT Slow rellease or Controlled release. There is someting in the coating that does not agree with me.

[drew410 in reply to Hidden]

A lot of consultants have a fixation about anti-D's. Easy way out and does not require them to actually think it through. No better than quacks - m'duck!

[Hidden]

Hi petal, yes i hope so, as ive have hunted everywhere, and cant find a reference to the dosage for this drug, i was hoping that one of the professionals would be able to tell me, and im not depressed, despite my little wobble a while ago.

jean

[Hidden in reply to Hidden]

Glad to hear that Jean, sometimes, we all have a melt down.

Does the leaflet with your med. not give the info for how high you can go for RLS use.... I know some leaflets give that info when using the Parkingson's meds for RLS.....

Irene...

[Hidden]

hi petal, nope, its just telling about parkinsons, and really high doses

jean

[Hidden in reply to Hidden]

So, Jean, if you are not getting an answer from on here, i guess you have to hope your own doctor knows the highest dose to use for RLS...

Irene....

[Hidden]

well, not really, as hes a bit cross with me, about the depression thing, and im looking for another doctor at the moment

[Hidden in reply to Hidden]

Oh dear, silly doctor, hope you find another doctor soon Jean,

Irene..

[estjules in reply to Hidden]

Hello Jean, i'm sorry I cant answer your question on the highest dose you can go on the prolonged release of mirapexin. I'm on 0.52mg. My neurologist put me on that after the short term tablet wasnt working for me. This generally works for me but I can also take a small dose of clomazepan if needed. I also have depression which my doctor treats seperately & the possibility of the link between the two has never been brought up. I dont quite see where your Doctor is coming from there. I have to say i've been lucky with my gp's I was reffered straight away to a neurologist when I mentioned rls to them so I do hope you have better luck with a different Doctor. All the best.

[BobM]

Hello, re Mirapexin (Pramipexole)

I take 2 x 0.88mg 3 times a day so 5.28mg everyday and sometimes extra if its a really bad day.

[Hidden]

hi all, well im getting lots of answers, but none about the prolonged release version of this pill, you all take your pills at intervals during the day, but i only take one at night.

jean

[Hidden]

Jean looks as if you might have to try and find the answer somewhere else. I will inbox you with some suggestions....

Irene...

[Hidden]

hi Irene, did you forget to inbox me, or are you busy at the moment

jean

[Raphael]

Hello,

To the best of my knowledge 4 mgs per day is the most an RLS sufferer should take. More than this would cause Augmentation which in itself will then cause RLS to become even more unbearable.

Raphael

[Willie416 in reply to Raphael]

That is right. 4 mgs is the highest therapeutic dose for RLS. This does not include Parkinson's, where the level can be much higher. Good info to know, though I saw conflicting information in one of your later posts. RLS experts all agree on this that do know what they are doing. This post is good and correct information for all of us to know.

[Willie416 in reply to Willie416]

That dose is for the short acting form, correct?

[cheruk]

I take 5 x 0.088mg mirapexin every night for RLS. Doc advises me maximum dose is 6 tablets.

[Pippins2 in reply to cheruk]

The international RLS experts now recommend much lower doses due to the risk of augmentation. The higher the dose the greater the risk and so much more difficult to get off high doses. The new daily recommended dose of Mirapex ( Pramipexole ) is just 2 x 0.088 mg per day

Pipps x

[cheruk in reply to Pippins2]

Until last week i had been taking 4 every night but it had stopped working so well so my gp advised me to increase to 5. May i ask what is augmentation?

[Pippins2 in reply to cheruk]

There are hundreds of posts about augmentation. If you put it in the search box it will bring them up. Kaarina can you put up the augmentation link here please.

Basically it is something that can happen when taking one of the Dopamine Agonists meds eg Mirapexin.It is where you have to keep increasing your dose and it helps for a while then it doesn't and you have to keep increasing. It is the medication itself that is worsening the RLS. Signs of augmentation are needing to up your dose, RLS starting earlier in the day. symptoms starting up after shorter periods of rest and relaxation. Sometimes symptoms spreading into other body parts most commonly the arms and med not working so well at night. If you scroll through the posts you will see lots of members having this problem. Does this sound like you? Unfortunately most doctors are not aware of augmentation and just keep on upping the dose which is the wrong thing to do

Pipps,

[Kaarina Administrator in reply to cheruk]

This link may help you understand about augmentation, cheruk:

sleepreviewmag.com/2015/02/...

[Pippins2 in reply to Kaarina]

Thanks Kaarina wish I could do links! X

[involuntarydancer]

I would be very, very anxious about following your GP's advice on this. It is sadly far from rare for GPs to be completely at sea when it comes to the intricacies of dealing with RLS - they often get it wrong. Do the research for yourself - it is your body and your condition and you have to be satisfied about what you decide to do. But I would be very surprised if upping your dose of mirapexin will have any lasting benefit - before you know it, the new dose won't work and the higher the dose of mirapexin the more difficult your situation will get.