Buprenorphine/Naloxone Side Effects - Restless Legs Syn...

Restless Legs Syndrome

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Buprenorphine/Naloxone Side Effects

Yorkie111 profile image
12 Replies

Hello! I am trying to get info to resolve a problem I am having with my feet/ankles swelling quite a bit all day long. My cardiologist office thinks it is a side effect of the Buprenorphine I have been taking for a few months for my RLS. I’ve found a couple of references to minor swelling being a side effect but I am almost to the point I can’t wear my shoes! Has anyone else had this problem? Thanks!

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Yorkie111
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12 Replies
SueJohnson profile image
SueJohnson

You might want to take a diuretic but be sure it is a potassium sparing one.

Yorkie111 profile image
Yorkie111 in reply toSueJohnson

Thanks. Will try that.

Madlegs1 profile image
Madlegs1

What blood pressure medications are you on?

A lot of them can give ankle swelling as a side effect.

Yorkie111 profile image
Yorkie111 in reply toMadlegs1

Good thought but I’ve been on the same blood pressure meds for over 8 years. About a year ago I went on rosuvastatin. Thanks!

Joolsg profile image
Joolsg

No. I had leg swelling on gabapentin and pregabalin. But not since I reduced pregabalin down to a tiny dose.Buprenorphine hasn't caused any swelling.

Yorkie111 profile image
Yorkie111 in reply toJoolsg

Thanks Joolsg! It could be the pregablin. I’ve only been on it 2-3 months and the swelling has been going on a month but now getting worse. Maybe I should give it another month and see if it stops. If it doesn’t I’ll look at switching to pregablin.

Joolsg profile image
Joolsg in reply toYorkie111

Oh- didn't realise you were on pregabalin as well.It will definitely be pregabalin. It is a well known, common side effect of pregabalin.

mayoclinic.org/drugs-supple...

ChrisColumbus profile image
ChrisColumbus

While I don't take buprenorphine, fairly commonly peripheral oedema (fluid retention in the lower legs, feet or hands) and rarely angioedema (an allergic reaction causing swelling of areas of the face, hands or feet, or genitals) are known side effects. Jools hasn't experienced oedema on the buprenorphine but I see did on pregabalin, and as Madlegs writes these symptoms can also be caused by other drugs

Joolsg profile image
Joolsg

bicyclehealth.com/suboxone-...

It could be either or both of the Suboxone AND pregabalin.

It's noted as a common side effect of pregabalin and a rare side effect of suboxone.

Popsinlv profile image
Popsinlv

I had swelling problems while taking pramipexole/ tramadol. Started taking buprenorphine about six weeks ago, and the swelling went away.

Leeserann profile image
Leeserann

Hi,

I experienced this as well, after weaning off the pramipexole and moving to the gabapentin. It is a known possible side effect. Keep in touch with your doctor about it. It can rarely be a sign of something more serious. For me, as Sue sai, a low dosage diuretic was all I needed until the side affects gradually wore off. I don’t need it anymore. I took it for maybe 2 months.

Yorkie111 profile image
Yorkie111 in reply toLeeserann

Thanks. Glad to know the swelling is known to go down and I will see about a diuretic. I am getting ready to email my neurology PS and explain what is going on.

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