Pregabalin Dosage

[Lubopepper]

So im now up 250mg of Pregabalin per day, taken 30 minutes before bed. Getting aleast 5 hrs of unbroken sleep but my problem is that my RLS seems to be worse than ever while im sleeping. So just wondering what dosage did others on here take to eliminate the RLS? Im sure my last dose of Pramipixole was round about the 7th January, give or take a day.

[SueJohnson]

The average effective dose according to the Mayo algorithm is 200 to 300 mg. and you can go up to 600 mg.

[Lubopepper in reply to SueJohnson]

Thanks for replying. Up until a Christmas I was on 25mg of Fluoxetine, had been on this for near 7 year but have since reduced that down to nothing after reading comments on here about anti-depressants and Pregabalin, could that be hampering the Pregabalin from working as im sure this takes quite a while to be completely out my system.

[SueJohnson in reply to Lubopepper]

It could be.

[Clamire in reply to Lubopepper]

No, that low dose of fluoxetine that you stopped six weeks ago should not be affecting your RLS. Are you taking a statin, calcium channel blocker, testosterone, Metformin, Thyroxine or a PPI, currently? All these can make your symptoms of RLS worse than they have to be.

If you decide to try iron please take your iron at night on an empty stomach about two hours before bed. I prefer and use a form of iron called ferrous bisglycinate (56mg). It gets rid of my RLS in 1.5 hours for one night as well as many others on here. I highly recommend you try taking your iron this way. RLS has little to nothing to do with body ferritin levels (unless you’re anemic then raising ferritin will help) and everything to do with something called serum iron. Serum iron plummets at night (as well as dopamine) and we get RLS. If ferritin were a major component in RLS then you should have RLS 24/7, not just at night.

Here are more members’ experiences.

healthunlocked.com/rlsuk/po...

healthunlocked.com/rlsuk/po...

[Lubopepper in reply to Clamire]

Thanks will look into the Iron supplement.

[Clamire in reply to Lubopepper]

I’ll take that to mean you’re not on any of those drugs I mentioned?

[Clamire in reply to Lubopepper]

Just checking in and checking up on you. Your experience will help others.

[SwimLyn in reply to Clamire]

Hi Clamire-you mentioned serum iron in your reply to Lubopepper & wondered if there is a level that should be maintained & if so what it is ?

[Clamire in reply to SwimLyn]

That I do not know. The “normal range” will probably vary by country and metrics. Serum iron has a circadian rhythm. It drops as evening approaches and is lowest at midnight when it slowly begins to rise.

[Joolsg]

As your last dose of Pramipexole was 7 January, that's only 34 days ago.Early days.

Dopamine receptors take months to settle.

If you're getting 5 hours unbroken sleep at this early stage- that is very positive.

I wouldn't increase pregabalin yet.

It can take a while for the effects of fluoxetine to settle as well.

For now- maybe add 30mg codeine a few nights a week?

I think your RLS will improve dramatically with each month away from Pramipexole and fluoxetine.

[Lubopepper in reply to Joolsg]

Again, thanks for all the information.

[SueJohnson]

Did you ever have your ferritin checked?

[Lubopepper in reply to SueJohnson]

I had loads of tests done just before Christmas, as far as I know everything came back as normal.

[Madlegs1 in reply to Lubopepper]

"Normal" not good enough!

You need to be at least 100 and up to 200 would be better.

Go get your actual numbers from the surgery--- it's your information -- you are entitled to it --and don't be fobbed off by supercilious officialdom.

[SueJohnson in reply to Lubopepper]

I agree with Madlegs1. What is normal for others is not normal for those of us with RLS.

[nick-the-turk]

I take 150mg at 5 in the afternoon and 300mg before bedtime along with 60mg codeine phosphate and lucky to get 3 maybe 4 hours of broken sleep and pillows and quilt etc can end up anywhere so if your getting 5 hours of unbroken sleep maybe the medication is working for you and I wish you well praying you get many more decent nights sleep because RLS is horrible to say the least