Pregabalin dose timing?

[C82021]

Going from 1500mg Gabapentin to (starting dosage) Pregabalin 75mg twice day. My RLS mostly affects me from 7pm through 1am. At what times would you take the two doses of Pregabalin?

FYI, I asked AI the question this was the very informative response.

for RLS

Generating answers for you…

Restless Leg Syndrome (RLS) can be a challenging condition to manage. Pregabalin is a medication that can help alleviate the symptoms of RLS. According to the dosage guide provided by Drugs.com, the recommended starting dose of pregabalin for RLS is 75mg twice a day12.

It is important to take pregabalin at the same time every day to maintain a consistent level of the medication in your system. The best time to take pregabalin depends on your individual needs and lifestyle. However, it is generally recommended to take the medication at 12-hour intervals1342.

Based on your schedule, you could take the first dose at 7am and the second dose at 7pm. Alternatively, you could take the first dose at 1pm and the second dose at 1am. It is important to consult with your doctor before making any changes to your medication regimen.

I hope this information helps you manage your RLS symptoms. Please let me know if you have any other questions or concerns.

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[SueJohnson]

You don't need to take it in 2 doses. Take it in 1 dose 1 to 2 hours before bedtime.

AI can get things wrong. Twice a day is for neurological pain, not RLS.

And going from 1500 mg to 150 mg of pregabalin is equivalent to going to 900 mg gabapentin. You will suffer from withdrawal symptoms doing that. Ask for 250 mg.

[C82021 in reply to SueJohnson]

Thanks Sue, I did ask, And DR. insisted I start with 150mg, then increase after outcome. I am under VA care, that's my option.

[SueJohnson in reply to C82021]

Do you have enough gabapentin left that you can add to the pregabalin even though your doctor doesn't want you too. Otherwise prepare yourself for withdrawal symptoms which can include insomnia, headache, nausea, anxiety, diarrhea, flu-like symptoms, pain, excessive sweating, dizziness, confusion, and palpitations.

Good luck. Doctors can be so stupid at times.

[Joolsg]

As Sue says, no need to take pregabalin in split doses twice a day. That is for neuropathic pain.And she's right about the dose equivalence, although I recently read an article that states it is difficult to work out the correct dose equivalence because of the different ways both drugs are absorbed and excreted.

But, as you have no choice because your doctor will only give 150mg pregabalin, take it all in one dose at night and, if you struggle, go back to him to get the full 250mg.

[Tanker1]

I generally agree with the advice already provided. I switched from 1800 mg of gabapentin (taken in 3, 600 mg doses) to 300 mg of pregabalin with no transition (i.e 1 day). I had no issues with the transition. I take it all 1-2 hours before I attempt to fall asleep. I have PLM that primarily effects me between 9:00 pm and 3:00 am so its best for me to take it all at once in the evening. I do think I have some side effect, the main ones being daytime sleepiness and memory issues but at least I can sleep. Its an unfortunate tradeoff.

I recommend extreme caution using AI for any medical advice. These things are not really AI, but rather very complex text generators. The results of a query are often riddled with serious errors and even complete fabrications.