Low dose Naltrexone

[BluGenie]

I just had a health care person suggest I research Low Dose Naltrexone for my RLS.

so I’ve been reading on it a bit and have seen cases where it’s helped people. There was even a post on this site, I believe about 2014, regarding this. But I’ve never seen any current discussion on.

Has anyone tried it ? If so, how has it worked?

Thank you

[SueJohnson]

It can help as you have read. Don't use any opioids at the same time.

Other posts healthunlocked.com/rlsuk/po... healthunlocked.com/rlsuk/po... healthunlocked.com/rlsuk/po... healthunlocked.com/rlsuk/po... healthunlocked.com/rlsuk/po... healthunlocked.com/rlsuk/po... and many others. Just put LDN in the search box.

[BluGenie in reply to SueJohnson]

Thank you Sue

[Joolsg]

Not if you are still on Pramipexole.So first, go through withdrawal, then when you are about to drop the last dose of Pramipexole, you can start LDN.

It has helped some people, to varying degrees.

In the UK it is only available on private prescription from private clinics and costs around £40 a month.

[BluGenie in reply to Joolsg]

Why do you need to wait until off of pramipexole?

[Joolsg in reply to BluGenie]

Because Pramipexole over excites all your D1 dopamine receptors, driving the worsening of RLS. It breaks through all other treatments.So, if you need LDN to treat severe RLS, there's no point adding other meds until you get off the drug that's causing the severe RLS.

Recently we had a woman who was taking Pramipexole AND Buprenorphine. Of course the severe augmentation symptoms from Pramipexole broke through, and stopped Buprenorphine working.

You can START LDN about 3 weeks before the last dose of Pramipexole and it MIGHT help withdrawal symptoms.

[amrob123]

I belong to an LDN Facebook group. The results there are very mixed with some people finding complete RLS relief, others no change, and for others, worsened symptoms (sometimes only temporarily worsened). So the only real way to know is to try it for yourself.