Low Dose Naltrexone

[Doctorplacebo]

Hello All. Has anyone had any experience with low dose naltrexone (LDN)?

[Amrob]

Yes, I tried LDN recently.

My main issue is Periodic Limb Movement Disorder (PLMD) with occasional mild RLS.

Because my PLMs occur mostly when i'm asleep, it's difficult to ascertain how effective an intervention is. Especially given that i also take pregabalin and a low dose of clonazepam.

I started with an ultra low dose of naltrexone. Around 1mg from memory (the usual dose is around 4mg i believe). I had to take it first thing in the morning as it can cause insomnia.

The first batch that i took, i didn't notice any difference to my sleep / PLMD. What i did notice was that i had more energy and stamina when i took it. (I have chronic daytime fatigue that lasts two to three hours most likely the result of the medication i take).

I never increased the dose because of the issue with insomnia.

The second batch that i took, I didn't feel any difference. I wonder whether there was some mix up at the compounding pharmacy because the two batches were markedly different colours.

So, unfortunately because of all the things going on, i can't say definitively if it worked for me or not.

A small number of other people on this forum have tried LDN. Some with great success, others with none. Some have left this forum. You can search their posts using the search function at the top right of the screen on this site.

[SkyCop]

Didn't work for me. It also made me so sick to my stomach and weird feeling I stopped taking it after a month ... Tried it on/ off a few times but never seemed to help my RLS. Hope you have a better experience.

[Grammieof4]

I tried it for nerve pain (and I already have RLS.) It didn’t help me at all. Tried for 6 months

[Doctorplacebo]

Thank you, everyone, for your helpful replies. Sounds like it's mixed bag and the only way to know is to try it. If it gave me more energy as it did for Amrob that would be great although main goal is to reduce or eliminate the need for opioids. I don't know if I can get anyone to prescribe LDN, however, so it may be a mute point.

[JenHider in reply to Doctorplacebo]

Hi

I just saw your message.

I am on LDN I have been taking it for 7 months! It is having good effects all over!

Did you manage to try it? 😀