Summary of RLS resources

[ChickenTwisty]

These have all been posted before, I thought a stand alone post of current resources could be useful. You can select "Save Post" below and you won't have to dig through posts to find what your looking for it.

Mayo Clinic Proceedings (2021) mayoclinicproceedings.org/a...

Longitudinal assessment of buprenorphine effectiveness for severe restless legs syndrome and dopaminergic augmentation (March 2023).

Abstract presented at: SLEEP 2023; June 3-7, 2023; Indianapolis, IN. Abstract 0699.

neurologyadvisor.com/report...

my.clevelandclinic.org/depa.....

Dr Winkelman 2023 SLEEP address

youtu.be/h5Hyhmxli54?featur...(Not working as expected?)

Restless legs syndrome

AJGP - Volume 52, Issue 9, September 2023 www1.racgp.org.au/ajgp/2023...

Draft American Academy of Sleep Medicine Clinical Practice Guidelines released (March 2024)

aasm.org/wp-content/uploads...

Video accompanying draft guidelines youtube.com/watch?v=LbTrhIH...(Not working as expected?)

National RLS Opioid Registry

Massachusetts General Hospital has created a national registry to study the use of opioid medications to treat restless legs syndrome (RLS).

massgeneral.org/rls-registry

*** includes a list of quarterly updates

[Jumpey]

Thanks.Really helpful.

[Highlighters]

Big pharma clap trap

[Mongolia2020]

thank you ChickenTwisty. That is very helpful for those who have severe RLS for whom non-pharmacological remedies just are not enough, and who want to educate their GP.

Very useful to have it all in one place.

[ChickenTwisty]

Here is large genetic study published in full yesterday nature.com/articles/s41588-...

[ChickenTwisty in reply to ChickenTwisty]

This is the a technical report, there was a discussion article pisted here on it a couple of weeks back. It's a long technical read, the PDF is easier to digest. If I am reading it right (I started in it but skipped to 3 column discussion) these are the main points:

RLS heritability is eightfold normal population, higher heritability in women.

RLS is likely influenced by unobserved environmental factors. Identified need for tracking environmental exposures in genetically susceptible individuals. Hands up?

Confirmed that RLS is linked to neurodevelopment and neurotransmission, suggesting critical developmental periods for genetic contributions to RLS.

Identified several druggable genes and potential therapeutic targets.

Thete was significant genetic correlations between RLS, insomnia, depression, type 2 diabetes, osteoarthritis, and respiratory diseases. Healthy lifestyle choices may reduce RLS risk.