I find that swelling in either of my knees or ankles triggers my RLS. Since I had a knee replacement 6 months ago, the swelling happens frequently as both legs readjust to the post-surgical healing.
A new study revealed that ibuprofen and other NAISDS can cause fatal kidney disease, so my GP took me off all such pain medications, leaving me with only Acetaminophen for inflammation & swelling. I have also been on Tramadol and Pregabalin for my RLS for 5 years. It works well for that, but does nothing for the swelling & inflammation. Inflammatory pain is a constant issue, but I don’t know what to use now that works as well as ibuprofen. Any recommendations?
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Bganim1947
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I'm not sure where you are at, but I know in the US there is a product called Voltaren gel that used to be only obtained through a prescription from your doctor but is now available over the counter. It sounds very similar to what Madlegs1 is talking about. 😊 It's possible it is available in other countries, too. I haven't tried it myself but have heard good results from others and am considering trying it for my painful knees.
besides the other cream suggestions, switching to an anti-inflammatory diet would be helpful in the long run. I can tell you after a month or 2 of cutting out sugar and carbs and eating lots of vegetables. (And I did some fasting too) a lot of my inflammation went away.
I need to take my own advice right now. since the Holidays I've been eating poorly and am now back in pain with inflammation.
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RLS and Osteoarthritis 
Total Knee Replacement and RLS
Hi All, having pain at the back of my knees?
Stabbing, Needle like pains before RLS kicks in
