I find that swelling in either of my knees or ankles triggers my RLS. Since I had a knee replacement 6 months ago, the swelling happens frequently as both legs readjust to the post-surgical healing.
A new study revealed that ibuprofen and other NAISDS can cause fatal kidney disease, so my GP took me off all such pain medications, leaving me with only Acetaminophen for inflammation & swelling. I have also been on Tramadol and Pregabalin for my RLS for 5 years. It works well for that, but does nothing for the swelling & inflammation. Inflammatory pain is a constant issue, but I don’t know what to use now that works as well as ibuprofen. Any recommendations?