I’m trying New drug : Has anyone tried... - Restless Legs Syn...

Restless Legs Syndrome

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I’m trying New drug

Topmong1 profile image
8 Replies

Has anyone tried aripiprizole????

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Topmong1 profile image
Topmong1
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8 Replies
Elffindoe profile image
Elffindoe

Do you mean aripripazole?

If you were to google it you will see it is an "atypical" antipsychotic drug.

You will also see it's a dopamine D2 partial agonist

Topmong1 profile image
Topmong1 in reply to Elffindoe

That’s the one!!!!! It’s dopamine therapy.

Elffindoe profile image
Elffindoe in reply to Topmong1

It's not as simple as that.

It's a therapy for schizophrenia designed to balance dopamine and serotonin.

This doesn't mean it's of any value for RLS.

Do we need nore dopaminergic therapies for RLS?

The latest research on meds for RLS has moved away from dopamine.

I wouldn't suggest anybody try even if anybody would prescribe it.

Sorry

Topmong1 profile image
Topmong1 in reply to Elffindoe

I have adhd and tic disorder too so I think here’s trying to balance that out

Elffindoe profile image
Elffindoe in reply to Topmong1

I see. Yes it could be

Elffindoe profile image
Elffindoe in reply to Topmong1

In that case it can help the attention deficit and tics, but may also help RLS.

Hard to say, because the 3 things are associated with different areas of the brain.

E.g. both DAs and opioids are good at treating RLS.

However whereas DAs can affect the reward system and cause impulsive behaviour, opioids cause euphoria

Pramipexole never gave me euphoria.

Eryl profile image
Eryl

Like other meds It treats the symptoms but not the cause.

Elffindoe profile image
Elffindoe in reply to Eryl

That's right, symptomatic only.

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