An Update Post from Lonely7

[Lonely7]

A good family friend recently told me about this available over the counter drug in Canada. She has used it for a while now and has found tremendous amount of relief for RLS and other leg problems. I realize that most if not all the people on this blog do not live in Canada. Of course it might be available outside Canada as well. But I just wanted to let folks know about this because I am about to try it for my situation.

And while writing this I would like to share with everyone who responded to my post that for the past few days, couple of weeks in fact; I have been doing not too badly. My Neurologist is attempting to get me switched from Mirapex and Sinimet (spelling?) to Gabapentin which I have learned from past experiences I have to do very gradually. I am down from five or six Mirapex to three and sometimes I can get away with two. But on Sunday evening past I bravely attempted to go it on one Mirapex and had a real bad reaction for about four hours. It was then that I took another Mirapex and things began to level out again. I am still on the Sinimet which does not seem to be bothering me very much, but does bring me quick relief. So that's my update and now I am going to try Venixxa. Which in due course I will report on as well.

Lonely7

Servier Canada announces the launch of VENIXXA™, an over-the-counter oral treatment to relieve signs and symptoms of chronic venous disease and hemorrhoids

NEWS PROVIDED BY

Servier Canada Inc.

Nov 10, 2017, 06:00 ET

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LAVAL, QC, Nov. 10, 2017 /CNW Telbec/ - Servier Canada announces that VENIXXATM (micronized purified flavonoid fraction, MPFF), is now available in pharmacies as an over-the-counter oral treatment for patients with mild-to-moderate chronic venous disease or hemorrhoidal disease. VENIXXATM has been extensively tested in various controlled trials and large registries and is currently available in more than 33 countries around the world.

Chronic venous disease of the legs is characterized by signs and symptoms ranging from a sensation of heavy and/or painful legs, night cramps,1spider and varicose veins, edema or ulcers. In the Vein Consult Program2—an international, observational survey completed by 6232 general practitioners, it was estimated that approximately 74% of adults suffer from mild-to-moderate chronic venous disease. "As physicians, we have very few options available for these patients apart from mechanical treatments such as compression stockings and endovenous procedures. Although these are very good alternatives, a treatment that addresses the inflammatory process and loss of venous tone related to venous disease is welcome" stated Dr. Douglas Hill, President of the Canadian Society of Phlebology.

Hemorrhoids are a common condition among adults in North America; it is estimated that at least 50% of the population +50 years old has suffered from hemorrhoids at one point in their life. The most common signs and symptoms related to this disease are pain, bleeding and discomfort.3

Patients often experience a decline in their quality of life as each of these diseases progresses.4

Servier Canada

The over-the-counter drug market is expanding in Canada, and Servier Canada is proud to enter this market. "The launch of VENIXXATM stems from Servier`s priority to provide effective and innovative treatment options, to Canadian patients. We will leverage our international expertise in vascular disease, to raise awareness of chronic venous disease, hemorrhoidal disease and their consequences, as well as to work with health care providers to ensure that patients are provided with appropriate care." stated Frederic Fasano, Chief Executive Officer of Servier Canada.

Servier is an international pharmaceutical company governed by a non-profit foundation with its headquarters in France (Suresnes). With a strong international presence in 148 countries and a turnover of 4 billion euros in 2016, Servier employs 21 000 people worldwide. Entirely independent, the Group reinvests 25% of its turnover (excluding generic drugs) in research and development and uses all its profits for development. Corporate growth is driven by Servier's constant search for innovation in five areas of excellence: cardiovascular, immune-inflammatory and neurodegenerative diseases, cancer and diabetes, as well as by its activities in high-quality generic drugs.

Servier Canada was established in 1978 in Laval, Quebec and employs over 300 people across Canada. Servier Canada is currently marketing medicines in Cardiology, Hematology and Diabetes, and will soon market oncology products indicated as treatment options in hematological malignancies. For additional information please visit our website at servier.ca.

[Joolsg]

Hi Lonely7

Mirapex and sinemet are both dopamine agonists. Why are you on both? Why are you reducing mirapex? Are you in Augmentation?

Reducing mirapex will produce withdrawal symptoms and it’s hellish. You’ll need a strong painkiller and zolpidem sleeping pills to help you through it.

Interesting post about the haemorrhoid pills helping RLS. I wonder if it works in a similar way to Pyridamole which Involuntary Dancer is having good results from? That is a blood thinner. Maybe this Canadian pill thins the blood.

Thanks

[Lonely7 in reply to Joolsg]

Hi Joolsg:

Sorry it took me so long to get back to you. As you know I went through a very, very difficult time coming off Mirapex which left me with absolutely nothing to control the hellish torture of RLS. I had only been on Sinemit a short time and it was the only control I had left. I would have ended it all without that help. It is still helping to control my RLS until Gabapentin cuts in. Tomorrow I see my Neuro and I am going there armed with information like I have never before had. I hope he is willing to listen and act on a lot of it. Depending on the results I will also see my GP afterwards to see what he can do for me. Hopefully things will then be a little better in all directions. Thanks for all of your support. It really means a lot to me.

Lonely7

[Joolsg in reply to Lonely7]

I am really hoping he listens. Sinemet is also a DA and you need opioids to get off that as well.

I know exactly how you feel. Lots of us have been in that dark place during withdrawal.

I am now off ALL dopamine agonists and on OxyContin and pregabalin. I would never take another dopamine agonist.

I do not get RLS in the day anymore and if I get it in the night it is very mild and a few muscle training exercises resolve the sensation.

Gabapentin won’t help while you’re still on sinemet sadly.

It takes about 3 weeks after the last sinemet for it to start working.

Good luck and I really hope you get help getting off sinemet.

Thinking of you

[Smiffyliz in reply to Joolsg]

Does it actually say it helps RLS. I could only see reference to varicose veind

[Joolsg in reply to Smiffyliz]

Hi smiffyLiz,

Which drug are you referring to? Sinemet,Oxycontin, Pregabalin or gabapentin?

Sinemet is a dopamine agonist so is often prescribed for RLS. Oxycontin is an opioid and so works well for RLS. Pregabalin & Gabapentin are alpha 2 delta ligands used as anti seizure meds but are used off licence for RLS.

I don't think any of them would help varicose veins.

In other posts, Dipyridamole has been talked about as a possible help for RLS and that is a blood thinning drug, so presumably might help varicose veins. A US study found it helped patients with RLS and so Involuntary dancer and Lotte have been trying it with some success. Is that the drug you are asking about?

take care,

jools

[Joolsg in reply to Smiffyliz]

Just realised you are talking about the drug Lonely7 mentioned above- venixx. Did you mean to ask him rather than me?

[Smiffyliz in reply to Joolsg]

Not sure who I was asking just several of posts said the drug helped RLs but sorry maybe yours didn’t

[Joolsg]

Hi Loney7

I see Involuntary Dancer has already given you brilliant advice on Augmentation and how you can get off mirapyand sinemet.

Follow her advice and you will find relief from the hellish situation in which you find yourself.

It is difficult but possible with the help of your doctor and opioids.

I will be thinking of you and sending you positive thoughts.

Jools

[Smiler53]

Hi Lonely, Tnx for the update. Hope all goes well. Keep posting your progress. Wishing you a peaceful night. x

[Hidden]

Hello all you wonderful folks on here who suffer as I do and yet you are so helpful and comforting to me.

First, let me say that somehow I got another username in here i.e. Toslo2018 and I have not yet figured out how to delete it.

Aside from that unpainful matter I just want to tell everyone where I am right now. I have with some great difficulty come off Mirapex. I was on it for years and I wanted to get off it because it was giving me some terrible side effects which were getting worse and I was about to become a walking mummie or a walking dead man or something terrible like that. I am still on Sinemet which I have not been on very long, and without that I would have no relief at all and I don't know if I could take that suffering again right now. My Neurologist has me on Gabapentin but after two weeks or a little more I can't see where it is helping this RLS at all. I understand that it takes time for it to cut in. So I will wait for that. On Wednesday of this week I go back to my Neurologist and I am going to ask him to follow some of, what to me, is wonderful information and advice on this site, such as the various supplements and the complete iron treatment. I am going to ask him about getting the iron treatment by interveinous. (hope that is spelled right). I hope he will listen. My wife has followed this site as well and is going with me when I see my Neurologist and she will surely back up everything I will have to say about possible treatments for this RLS which I have learned from you wonderful folks on this site. On the days and night that I am attacked I cannot even sit down at the computer to read or reply to anyone or anything on here. So please excuse my sometimes long absence. I am so glad I found this site. It is being a real life saver to me. Thank you all so much.

Lonely7 (Not Toslo2018 which I will try to delete)

[Vesa in reply to Hidden]

Hi Lonely7,


I have just sent you an email to try and resolve this issue! Could you please have a look? Let me know if you haven't received it. Best wishes,

[Hidden in reply to Hidden]

I’m so glad that you are getting the help you need! Good luck with the neurologist! Great idea having your wife go with you. It’s helpful, but also quite sad to need backup in order to get through to doctors. I’m going through the same thing with the possibility of another awful augmentation period coming my way and needing my husband’s help to get my doctors to take me seriously. Keep us updated!