I suffered with RLS from age 30 until I turned 60. I used to have to stay awake every night i order to attempt to alleviate the nightmare pain and non-stop movement in my legs.
It became so bad I felt I couldn't go on with it much longer and had thoughts of ending it all.
I then was referred to Wrightington Hospital near Wigan and the consultant suggested I try Fentanyl. They weren't keen on subscribing Fentanyl as it can have sever side effects for people who aren't used to such a powerful narcotic type drug. Fortunately, because of other health conditions I'd been taking Tramadol and my body coped nicely with Fentanyl.
Within a few hours of placing a 50mg Fentanyl patch on my upper body, the RLS stopped. That was 10 years ago and the only time the RLS returns (with a vengeance) is if I'm late changing the patches. Patches must be changed every three days and it really does pay not to be late swapping them!
Obviously Fentanyl won't be the answer for everyone, but it certainly works for me.