I have very serious RLS. and after taking pramipexole for nearly 20 years the drug is no longer working. Nothing else seems to help - and the medical profession have finally admitted that Pramipexole makes the condition worse. If I try to cut down or substitute another drug the symptoms become completely unbearable. I cant sleep and when I do I sleep walk, fall down stairs, drink bleach (!) get increasingly delusional and the discomfort and mental anguish is beyond description. Is there anyone out who knows if there is a detox program or some sort of medical support group.