I ran out of my Estradiol 1 mg prescripion about two weeks ago. Made appointment with new doctor for last week in January. Guess what? My restless legs have disappeared! After suffering for two solid years of agonizing discomfort. I never suspected that it might have anything connection to my HRT (hormone replacement therapy) prescription! After realizing that I was sleeping through the night quite comfortably, and not having the agonizing leg cramps, burning, pulling and discomfort of the RLS, I looked up Estradiol to see if there was an information about RLS and Estradiol. Look it up. Feeling better, now & hoping it will continue.