I have to update you guys on mums progress since taking your collective advice. Happy to say that we removed the Anti depressant (Amitriptlyne) and mums legs stopped jumping within 24 hours and have not returned now for nearly 3 months the dose she was on was tiny as we had dropped it gradually but it was still affecting her legs. What a difference it has made. She still takes the low dose of Pramipexole and many other tabs for her other aliments. Just shows how bad those anti-d's can be I would recommend anyone on them to try to get off them.