I'm prescribed 2 x 0.18 mg Pramipexole a day. I take the first during the evening and the second during the night. I've found that I don't get any relief until two hours after taking the first dose. It used to take up to one hour for relief but the time has increased during the last year. Does anyone else find it takes a long time until the drug works? If only there was something which gave almost instant relief!