I've had RLS for 25 years, and been on Pramipexole plus Temazepam for 8 years, which generally suppressed the symptons well, although like many fellow sufferers it went in waves. My GP recently told me to stop taking the Temazepam as apparantly it should only be taken for a few weeks at a time (funny, as he reviewed my medication every 6 months). Since stopping the Tem, the affect of the Pramipexole has diminished until I wasn't getting more than 1 to 2 hours broken sleep each night, so GP has switched me to Neupro. Did first week on 1mg, didn't work, so have now increased to 2mg. Wondered if the patches discharge more when first applied, or whether they discharge equally over 24 hours. Any best practice for using the patches would be welcomed. Also lost my job this week, so stress is presumably adding to the problem.