Researchers have identified two proteins that work together to drive neuroinflammation in acute conditions such as microbial or autoimmune encephalitis, and in chronic conditions such as multiple sclerosis.
In a study published today in Nature Immunology, a team led by Prof. Philippe Gros show that genetic inactivation of this protein pair blocks neuroinflammation and prevents the appearance of disease in animal models of multiple sclerosis (MS). The findings could pave the way for development of novel therapeutic approaches in inflammatory diseases such as MS.
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