Simplifying

[CheshireKatz]

youtu.be/X2ZWLI6LrMk(Not working as expected?)

Lot of work on the pause button it's worth the time and energy if you can skim through.

[Jonesbones]

A thought that came to mind was the case definitions cover the entire spectrum when after three years a distinct alteration has taken place.

Defining a butterfly by chrysalis stage does not see the whole development that much has become clear for me now in a befuddled mind.

[Arianne in reply to Jonesbones]

My belief that one criteria was for the convenience of the medical profession when individuals vary with symptoms/having other conditions caused by a broken immune system. Personalized treatment is the new kid on the block making no sense if placing under one label with standardized treatment protocols prescribed.

[Jonesbones in reply to Arianne]

An ideal future that with more investment in research one day we will reach there. Until then making the best of what there is.

[Ian123]

Provides a lot of information in a clear concise format. Thanks for sharing.

[Len607]

Becoming a simple test a hospital carried out as supporting evidence during diagnosis moves on the long waiting times patients experience now with all results are normal.

[readerlist]

IL-6 can operate by two pathways, the classical signaling IL-6 pathway which is anti-inflammatory and instigates tissue repair, and the trans-signaling IL-6 pathway which is pro-inflammatory.

Inhibiting the pro-inflammatory IL-6 trans-signaling has also been shown to improve cognitive dysfunction and neuroinflammation.

When IL-6 is released by the muscles during exercise, it normally has an anti-inflammatory effect this IL-6 released by exercised muscles is classed as a myokine.

Something may have gone wrong in ME/CFS, such that the IL-6 released during exercise somehow becomes pro-inflammatory rather than anti-inflammatory. This might explain why exercise causes post-exertional malaise in ME/CFS patients.

journals.plos.org/plosone/a...

[rocketronnie]

Imagine what proper research funding might find.