Lot of work on the pause button it's worth the time and energy if you can skim through.
Simplifying: youtu.be/X2ZWLI6LrMk Lot of... - Ramsays Disease
Simplifying
Written by
CheshireKatz
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A thought that came to mind was the case definitions cover the entire spectrum when after three years a distinct alteration has taken place.
Defining a butterfly by chrysalis stage does not see the whole development that much has become clear for me now in a befuddled mind.
My belief that one criteria was for the convenience of the medical profession when individuals vary with symptoms/having other conditions caused by a broken immune system. Personalized treatment is the new kid on the block making no sense if placing under one label with standardized treatment protocols prescribed.
An ideal future that with more investment in research one day we will reach there. Until then making the best of what there is.
Provides a lot of information in a clear concise format. Thanks for sharing.
Becoming a simple test a hospital carried out as supporting evidence during diagnosis moves on the long waiting times patients experience now with all results are normal.
IL-6 can operate by two pathways, the classical signaling IL-6 pathway which is anti-inflammatory and instigates tissue repair, and the trans-signaling IL-6 pathway which is pro-inflammatory.
Inhibiting the pro-inflammatory IL-6 trans-signaling has also been shown to improve cognitive dysfunction and neuroinflammation.
When IL-6 is released by the muscles during exercise, it normally has an anti-inflammatory effect this IL-6 released by exercised muscles is classed as a myokine.
Something may have gone wrong in ME/CFS, such that the IL-6 released during exercise somehow becomes pro-inflammatory rather than anti-inflammatory. This might explain why exercise causes post-exertional malaise in ME/CFS patients.
Imagine what proper research funding might find.