Ramsays Disease
567 members466 posts

Low Dose Naltrexone

Working on neuro inflammatory research for Fibromyalgia at Stamford University Dr Jarred Younger trialled Low-Dose Naltrexone ncbi.nlm.nih.gov/pmc/articl... .The information gained suggested further research that also included the ME/CFS population would be useful in understanding the effectiveness as a treatment cortjohnson.org/blog/2015/0...

The possible benefits of down regulating the micrglia in the brain while understanding the mechanism by which a low dose of the opioid antagonist naltrexone (LDN), an agent used clinically (off-label) to treat cancer and autoimmune diseases, exerts a profound inhibitory effect on cell proliferation.


LDN causes a compensatory increase in an endogenous opioid, the opioid growth factor this short term blockade of the opioid receptors provided a breakthrough in auto immune conditions that were not down regulating the inflammatory response.

Naltrexone was designed for opiate addicts using around 50 -100mg doses, the use use off label at 1.5 - 4.5mg treating cancer pain and HIV/AIDS this of label use is not researched by the drugs companies as any money possible has already been made, hence a low cost for medication under £1 per day.

More information at ldnnow.co.uk/

8 Replies

Came off NSAIDs with side effects on liver and stomach now on 5mg of LDN no side effects showing, monitored close by local med school I am happy with my choice.


Taken so long getting where I am at now any changes are have too


All I can say is nothing bad happening for me no regrets.


Used in treatment of MS (Multiple Sclerosis)




I started reading more of the items not very good at staying focussed when other things get my attention. Lose the plot very easy but dont we all LOL

1 like

I have read about this but is anyone in the UK able to prescribe and monitor this treatment? Is it available at all here?


Hi there, this is my first post on this forum.

LDN is available in the UK, but you may have to go private. I've been offered it by a non-NHS doctor after a set of tests I had (MFP). I'm awaiting further test results and may take the plunge after that.


Finding a doctor willing to prescribe ldnnow.co.uk/27101.html

or privately at prescribe4me.co.uk/LowDoseN...

Available but not been able to patent for autoimmune takes away any interest in clinical trials for drugs companies.