The above is my wife, my name is Brian, Ruth`s husband. She has just been diagnosed with PSP The effect is that she has lost of her voice, which has gradually happened over the last twelve months, until now all she can manage to say is yes and no very weakly. The neurologist told us that in time she will not be able to even make the slightest noise at all, and that other parts of her body will be affect in time but could not say at what pace this will take. Reading some of the community letters it seems that a lot of pain is involved as the condition progresses. As you can see we are very new to this and know very little about PSP.