Hello. We are aware that Sinemet is used for regular Parkinsons but is used for PSP patients and can help alleviate some of the symptoms not all and not guaranteed. Initially over the first 3/4 months Mum's response was positive and her speech became less slurred and her movement better, however, the side effects she suffered with the worst was dry mouth and swallowing, but it's hard to know if this is the medicine or the disease. Also sweating has become increasingly worse. Mum finds everything unbearable and blames the Sinemet for everything, but really her symptoms have progressed and a lot of it is the disease sadly. Has anyone else had experience on Sinemet? Equally has anyone had experience of any other medication that has made a difference?