I came back to MD Anderson after neoadjuvant therapy of Firmagon + Erleada after 11 weeks and my white, red, hemoglobin are below normal.
White is 2700.
I am recent diagnosed localized 4+3=7 with 4 cores intraductal and three of those cores are cribriform. I have a bulky tumor that 4 surgeons referred me to radiation.
I am planning on brachyboost. (HDR + proton) in feb thru march.
Has anyone had this reaction to Erleada?
I've had a couple side effects with this drug, it can lower WBC. I didn't expect to see the RBC and hemoglobin also.
Doug
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I had somewhat of the same affect with 6 mos of Lupron only it was just my Hgb and RBC that were low.. Like Tall_Allen mentioned, after my testosterone came back the anemia went away but it took about 6 months after the Lupron was ended for it to happen. I was Gleason 7 (4+3) in 4 cores. I had SBRT + ADT. Everything seems to be good now. I'm at 1 year post Lupron and my PSA is less than 0.1.
I have come to learn of my uncle, at 84 he was diagnosed with prostate cancer, he was treated with radiation. After the treatment his blood levels were low, never had he low levels according to his wife (RN). 1 yr later he had myeloma which developed into lymphoma and died. She said he received transfusions weekly, at the end of his life he experienced severe back pain and threw up which looked like coffee grounds, he was transported to hospital, he was hooked up receiving blood and the tubes shot out of his body as his blood turned to sludge, he died 1 hr later. I am scheduled for brachyboost. Its a LOT of radiation. Would a prostetctomy along with follow up radiation be better. I was comfortable with the brachyboost but this cancer discussion keeps getting more and more difficult. I recently sent a sample back to the promise study, should my doctors order genomic testing?
"Would a prostatectomy along with follow up radiation be better?" That is the worst combination. The prostate shields nearby tissue. If you remove the prostate, those tissues get the full brunt of the radiation. That's why urinary problems are so much worse after salvage radiation.
IDK when your uncle was treated, but RT has gotten very precise. I have never heard of problems like his in patients treated in this century at top institutions. It may be that he had some older type of RT that is no longer used for PCa.
What's most important is that you get treated by an RO who has done a lot of such therapy.
it seems to me that with IDC-P the standard has always been RP.
Add Cribriform would enhance removal. I keep reading how radiation doesn’t respond well to IDC-P.
Yes I have bulky tumor, surgeons say get RT. What would they say if my tumor has shrunk to not have extra capsular extension, and negative margins? I’m entering my 4th month of neoadjuvant therapy (ADT & ERLEADA). PSA =.1, testosterone = 4.
If MRI reveals a candidate for surgery should I choose that?
I read where patients doing neoadjuvant therapy have a greater BCR vs adjuvant therapy with radiation. This was dated 2005 report. Would you know if this is correct?
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Very low testosterone after ADT not rebounding after 8 months post treatment
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