PSA Doubling-Time

[janebob99]

This plot shows the Cumulative Risk of Death from All-Causes for men with prostate cancer versus Time from Negative Bone Scan (without curative treatment). The different lines show the effect of different PSA doubling times (DT), ranging from DT 15 months. The lines are essentially straight lines, indicating a linear increase in the Incidence of Death as Time increases. The takeaway is that very short doubling times (DT < 3 month) predict a much greater chance of death than longer doubling times.

Bob

[Justfor_]

It should be the PSADT of untreated men which in principal is longer than that after RP. At least in my case the former was more than double the latter.

[maley2711]

I think I'd have a better understanding if you could provide a link??

[janebob99]

Sorry about that.

Here's the reference:

europepmc.org/article/PMC/5...

Fig. 3 shows other types of outcomes: risk of metastasis and risk of prostate cancer specific mortality.

Bob

Risk of Metatasis for different Doubling times

[dhccpa]

How does the negative bone scan fit in with the doubling time?

[janebob99 in reply to dhccpa]

Good question. That's just the way the authors decided to study the effects.

I think it implies that the group of men studied did not initially have metastatic cancer. (i.e., only localized PCa).

[dhccpa in reply to janebob99]

Thanks. Good info all around.