Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.

[janebob99]

These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to PSA Failure.

In the upper plot, Dutasteride increases the Doubling Time from, for example, 9 months to 18 months (factor of 2X).

In the lower plot, Dutasteride increases the Time to Disease Progression (intent to treat) from, for example, 9 months to 18 months (factor of 2X).

Dutasteride reduces DHT levels by more than 90%, and DHT is what "fuels" prostate cancer growth. Plus, it treats Male Pattern Baldness!

pubmed.ncbi.nlm.nih.gov/231...

Thanks to Kanzan for posting this article!

[Cooolone]

Thanks for posting!

[dhccpa]

Is PSA failure the same as castrate resistance?

[janebob99 in reply to dhccpa]

Yes, I believe they are the same.

[Yearofthecow]

That article is from 2012, and the sample size is pretty small, only 294

[janebob99 in reply to Yearofthecow]

294 seems like a lot of men to me...

[Bleed]

It's fascinating to see the potential benefits of Dutasteride in managing PSA failure in men. The data presented in the Kaplan-Meier plots indeed suggest a significant improvement in PSA doubling time and time to disease progression with Dutasteride compared to placebo.

The mechanism behind Dutasteride's effectiveness, namely its ability to reduce DHT levels substantially, makes sense considering DHT's role in fueling prostate cancer growth. Additionally, the added perk of treating male pattern baldness adds to its appeal.

However, while these findings are promising, it's essential to consider them within the broader context of prostate cancer management. Further research, including larger trials and longer follow-up periods, would help validate these results and better understand Dutasteride's place in clinical practice. Also we shouldn't forget about importance of using only reliable pharmacies to get only high-quality medications, including Dutasteride, here is one of the trusted pharmacies with a good reputation - topsup24.com

It's discussions like these that drive progress in medical research and patient care. Thanks for posting!

[janebob99]

Thank You for the great feedback!