Reduced cancer-specific survival of low prostate-specific antigen in high-grade prostate cancer

Conclusions: Patients with a PSA <4.0 ng/ml had poorer the prostate cancer-specific survival (PCSS) than patients with a PSA 4.0-10.0 ng/ml. Similar PCSS was found in patients whose PSA levels were 10.1-20.0 ng/ml in patients with GS 9-10 prostate cancer.

pubmed.ncbi.nlm.nih.gov/321...

[Don_1213]

Just reading the summary conclusions of the article doesn't answer this question - might this be because the men with the lower PSA were diagnosed later than the men with higher PSA? If there were 2 guys, one with a PSA of 2.0, one with a PSA of 6.0 - which one is getting the digital exam, which one is going to be coaxed into a biopsy? This seems to be proven actually since they also concluded that men with a PSA > 10.0 had poorer outcomes than the men with low PSA numbers. To me, that raises the possibility that the higher PSA is caused by further progression of the cancer and possible metastasis.

None of that was addressed in the summary - and there wasn't an immediate direct path to the actual paper. My opinion, based on the summary was "duh.."