Harvard and NASA have partnered up again, this time for a study of resveratrol. I thought it interesting especially as many on ADT wish to prevent muscle loss and it's accompanying bone loss.
A link:
Copy everything between the lines to access the article.
19 Jul 2019 --- As the pioneering space race hurtles forward, a NASA-funded study conducted by Harvard researchers is proposing supplementing astronauts with a nutritional compound commonly found in grape skin and blueberries, resveratrol, as a means of preserving muscle mass and strength. Published in Frontiers in Physiology, their study shows that resveratrol substantially preserves both ...
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If you pay attention to mice: "Based on these preliminary data that resveratrol may be harmful, caution should be advised in using resveratrol for patients until further studies can be conducted."
"In a randomized placebo controlled trial, Kjaer and colleagues showed that although resveratrol intake was not associated with prostate size or reduction in prostate serum antigen levels, it was associated with lower levels of androgen precursors including androstenolone (DHEA) and therefore may have a relevant effect in benign prostatic hyperplasia and cancer growth [53]. These findings are consistent with previously pre-clinical work reporting that resveratrol suppresses prostate cancer growth in rat models, an effect largely mediated through down-regulation of androgen receptor expression and suppression of androgen responsive glandular kallikrein, an orthologue of the human prostate specific antigen (PSA) [54]."
The last sentence of concluding remarks--conflict of interest--footnotes and grants:
"Understanding how these dietary agents interact with cancer cells, the immune system and oxidative stress pathways may uncover safe, non-toxic and economical anti-cancer therapeutics in the future.
Go to:
Footnotes
CONFLICT OF INTEREST
There is no conflict of interest to declare.
GRANT SUPPORT
AT was supported in part by grants from the Ministry of Education, Culture, Sports and Technology of Japan, a Research on Allergic Disease and Immunology (H26-106) in Health and Labor Science Grant from the Ministry of Health, Labour and Welfare of Japan, the SENSHIN Medical Research Foundation (Osaka, Japan), the Aichi Cancer Research Foundation (Nagoya, Japan), and the 24th General Assembly of the Japanese Association of Medical Sciences (Nagoya, Japan). The funders played no role in the study design, data collection and analysis, the decision to publish or the preparation of the manuscript."
Ahh! Curcumin is another supplement studied and it was found when paired with quercetin it was enhanced.
An excerpt:
In one study, patients were given a combination of curcumin and quercetin (400/20 mg), a common flavonoid compound found in several supplements and foods. Compared to baseline colonoscopies performed prior to initiation of treatment, all five patients tested were found to have a decreased number of polyps and reduced polyp size after six months of treatment without other laboratory abnormalities and minimal adverse effects [31]. Although this study was limited and used a combination of both curcumin and quercetin, it raised awareness for future research testing the therapeutic potential of curcumin in pre-cancerous models [31].
My mother died of colon cancer in 2005. My father died from a "stomach cancer" when I was 12. I am glad to read the above! Seems like a side benefit!
That was a nice post by the NIH. It seemed to bolster the argument that synergy is more important than humongous amounts.
I wouldn't have found the article if you hadn't posted the 2012 study! I wanted something more recent and what I found was loaded!
Do you think the year matters? The mice died from the effect of resveratrol on their prostate cancer, no matter which year. Doesn't that lead you to question whether it is a good thing for humans with prostate cancer? In general, we've learned that antioxidants interfere with our body's mechanisms for destroying cancer.
All curcumin seems to do is interfere with PSA tests:
My doctors are well aware of that which I supplement with. My oncologist has told me not to stop. I have had an herbalist, a doctor of naturopathy, and a PhD in between grants go over what I take.
I must say this. The two doctors I see know what I supplement with and the consistency I adhere to. They expect to see a PSA that would be normal for me taking these supplements. That is my norm! That range is MY norm while I take supplements. Not someone doing a one off supplement regimen and NOT informing their doctors! If someone doesn't tell their their doctors what they are doing or wish to do of course that will raise concerns should their PSA rise.
In my case should my PSA rise that then would be a concern. They know that I am consistent with my supplements. My PSA did rise once, by 20%! Four days later I had a second PSA test and it was in range. My oncologist said that that is why the test's accuracy is regarded as less than--it could be better. He has probably had thousands of patients.
Before I had cancer I worked out rather heavy. At 5'6" I weighed over 200 lbs. I had a 32" waist and nearly 18" arms and calves. for the last two years before I was diagnosed. My PSA was stable within a range of 1.4 to 1.7 for 14 years and the 1.7 years were I believe my "Susan" years. When lifting heavy I took Twin Lab Joint Fuel which accounts for 702 mgs. of turmeric root extract standardized 95% curcuminoids. Interesting that Twin Lab's Joint Fuel formula also had 100 mgs of quercetin. Rather than piperine to push the curcumin they used bromelain.
In my case it would seem that curcumin has no effect on my PSA results but "Susan" did! Sadly she died of anti-phospholipid lupus at a rather young age. As for curcumin--I keep my docs informed. They expect my number to be what it is. A rise would mean something, another bad test or trouble.
For resveratrol--an excerpt from the 2016 study I posted:
"In a randomized placebo controlled trial, Kjaer and colleagues showed that although resveratrol intake was not associated with prostate size or reduction in prostate serum antigen levels, it was associated with lower levels of androgen precursors including androstenolone (DHEA) and therefore may have a relevant effect in benign prostatic hyperplasia and cancer growth [53]. These findings are consistent with previously pre-clinical work reporting that resveratrol suppresses prostate cancer growth in rat models, an effect largely mediated through down-regulation of androgen receptor expression and suppression of androgen responsive glandular kallikrein, an orthologue of the human prostate specific antigen (PSA) [54]."
"In a randomized placebo controlled trial, Kjaer and colleagues showed that although resveratrol intake was not associated with prostate size or reduction in prostate serum antigen levels, it was associated with lower levels of androgen precursors including androstenolone (DHEA) and therefore may have a relevant effect in benign prostatic hyperplasia and cancer growth [53]. These findings are consistent with previously pre-clinical work reporting that resveratrol suppresses prostate cancer growth in rat models, an effect largely mediated through down-regulation of androgen receptor expression and suppression of androgen responsive glandular kallikrein, an orthologue of the human prostate specific antigen (PSA) [54]."
There is a little more in my response to T_A above if you are interested. I didn't notice any difficulty gaining back size last summer when I worked again. I had to unfortunately take a "fluoroquinolone" break from exercise. Those drugs are brutal! Permanent damage to ligaments, tendons, joints and even soft tissue for some unlucky ones--yep!
Yeah the old achilles tendon snapper. I recall reading that in the drug side effects warnings that was multiple pages long. Thankfully I avoided that problem.
In a group of five men I mentioned the adverse fluoroquinolone reactions a year ago last summer. Three of us had experienced adverse reactions to fluoros, one an aortic aneurysm after having been prescribed fluoros.
A chiro I use frequently who started her career just before the fluoros noted that her patients that were prescribed fluoros, regardless of age, who had healed injuries, even old ones were attacked by the fluoros like low hanging fruit. She diagnosed mine.
As for aortic aneurysms--in our age group it was probably thought that--"Ah well! That happens to them when they get older" and just got pushed to the side for years as they just kept prescribing and injecting the drugs to prevent sepsis when doing biopsies and such! Cefdinir and Rocephin could have been used rather than a fluoro.
Where did aspirin come from? The history of drugs began with sourcing from plants.
I manufactured various drugs for14 years. I ran a production shift for three years. Some drugs produced were synthetic versions of drugs that can be sourced from natural plants.
As always, I say that each of us should keep our health care team advised as to what we take. I mentioned that in the post. You missed that? My oncologist has been involved in published studies.
I do enjoy the "Snidely" edge of your comments at times. It keeps me on my toes!
Happy New Year T_A! My best to you my snidely friend!
By the way--as far as standard, conventional treatments--you do set a bar!
You actually made my point - supplements ARE drugs and should have to pass the same bar of safety and efficacy that all drugs do. Just because you can buy them online doesn't make them safe or effective, plus, they are often falsely labeled.
A synthetic that was made--difficulty with some equipment in the beginning--the glitches or bugs or poor engineering and "design" by the equipment manufacturer. I looked at it and advised adding a pump to accelerate the flow of coolant to the rotating shaft seal--no more problems. The synthetic needs a prescription. When the equipment was failing I quipped that--"Why don't we just get rid of the lawn and plant some!"
A company worth billions isn't going to start a farm on their lawn! LOL! Synthetics make $$$ which --"makes the world go round"!
Sorry, I have no idea what you're talking about. Are you suggesting that the multibillion dollar supplement manufacturers have no incentive to test their products? I very much agree.
May 30, 2019 · Consider the drug Cosentyx, which the FDA approved in 2015 to treat psoriasis, a condition that causes red, scaly patches on the skin. It is not life-threatening in the vast majority of cases.
Agreed. FDA approval might mean something. It might not. It might mean good. It might mean harmful.
I eat food that isn't FDA scrutinized and hasn't been through RCTs. But I still think it's okay for me to eat fruit and veggies (horrors! I actually eat grapefruit and oranges picked from the trees in my yard! - no RCTs on my trees). Sarcasm intended.
No matter what anyone tries to tell me, I believe that it is incumbent on me to decide what to put in my body and how to deal with any health issues that I may have. I look at studies, lab testing, do my own tests when feasible, look at FDA, WHO, etc approvals or opinions. I then form my OWN opinion.
I don't know why someone would bow down to the U.S. FDA as the ONLY correct authority. Do they believe that WHO or CDC or Europe or.... are 100% wrong if they don't agree with the U.S. FDA? And if the FDA changes a stance, what does that mean? Was their opinion correct about a substance at one time and then the substance and its interactions somehow changed so the FDA updated their position accordingly? In essence, were they correct both times?
A thoughtful reply and intelligent analysis of the powers that be. I remember not long ago when the medical profession was trusted and revered --and that includes the FDA. They wouldn't do anything to harm you? No! The CDC? Of course each uro's specialty is usually the best plan for treatment.
Knowledge has that empirical aspect to it which either advances or at times disproves that which has been believed to be true. Discounting that which is promising, that which seems possible or is relatively new because one has long held, rigid, inflexible beliefs or a bias mires one in the present. Their present becomes their future. They have difficulty advancing.
Dr. Joseph Lister saw the need for an antiseptic while many colleagues thought it folly.
Dr. Edward Jenner would possibly be incarcerated today for the way in which he developed the small pox vaccine.
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