Nearly half of patients with giant cell arteritis achieve remission with upadacitinib

[perceptual63]

Great news for GCA patients! 😀

healio.com/news/rheumatolog...

[winfong]

I took Rinvoq for a short while. Just made me too tired to stick with it.

[PMRpro Ambassador]

Another Janus Kinase inhibitor - wonder what the others would do in GCA. 50% success is the same as Actemra/tocilizumab longer term.

[Sharitone in reply to PMRpro]

Do you think it is likely to be the same 50% - ie the ones where only the IL6 response is involved?

[PMRpro Ambassador in reply to Sharitone]

Will be interesting to find out. This

ncbi.nlm.nih.gov/pmc/articl...

says that Rinvoq interferes most with JAK1 - on the basis of the effect on IL-6 in the pathway (at least, that is what I understand from it ...) which suggests that the IL-6 effect is the important bit.

[Sharitone in reply to PMRpro]

Thanks, but🙁. We need something for those danged T cells and macrophages!

[PMRpro Ambassador in reply to Sharitone]

Well quite ...

This

ncbi.nlm.nih.gov/pmc/articl...

suggests JAK inhibition of IL-6 signalling affects B-cells. I hate immunology - I'm too old, this stuff was in its infancy when I was at uni!

[Sharitone in reply to PMRpro]

My husband (biochemistry) and BIL (ret'd GP) say the same. Not exactly simple, is it?

[PMRpro Ambassador in reply to Sharitone]

Certainly isn't! No one has written an "Immunology for Dummies" yet ...

[DorsetLady PMRGCAuk volunteer in reply to PMRpro]

Put me down for one when they do! 🤦🏻‍♀️