How cortisone/pred works - a new study reports on a potential target to replace steroids

[PMRpro]

I thought you'd be interested in this article about a study from Germany which has worked out how pred works - and knowing that is the basis for developing other drugs to replace it.

news-medical.net/news/20240...

[Rugger]

How interesting and hopeful for the future, if not in time for us.

Thank you for keeping us up to date, as ever! 🌺

[PMRpro Ambassador in reply to Rugger]

Particularly interesting to me - Erlangen was my husband's university!

[Rugger in reply to PMRpro]

Fabulous! 🌹

[pmrgcavictim]

Very good article PMRpro.

[Longtimer]

Thanks for that. While speaking to my son last night feeling very ill, and pain all over, he asked, what exactly are steroids?? I said a drug that dampens inflammation basically, and helps me!! although it's not supposed to if having fibromyalgia!!Have been booked in next week for a pain clinic seminar, but hate to say, don't expect answers......next move, to see GP and Max........At least the sun is shining, how is the weather where you are?

[PMRpro Ambassador in reply to Longtimer]

B£**&" cold and a howling gale! On Sunday it was 26C, yesterday and today it hasn't got to 10C never mind above it!!! Precious little sun either.

[Longtimer in reply to PMRpro]

Cold here, no rain for a change!........forecast not too good either!....

[PMRpro Ambassador in reply to Longtimer]

Had some rather emphatic April showers yesterday - appeared out of nowhere!

[Longtimer in reply to PMRpro]

Few days ago heavy showers/ gales......trees down.....sure I feel worse in cold damp weather!..

[PMRpro Ambassador in reply to Longtimer]

I do - why I hate the UK!!

[Longtimer in reply to PMRpro]

Don't blame you!.....

[Miacaro45 in reply to PMRpro]

Thank you for the article. I am going to give it to my rheumatologist. I can always count on the latest information from you. It was 85 degrees here in Atlanta, Georgia-sorry.

[Lico in reply to Longtimer]

Very warm here, I live in Spain🥵

[PMRpro Ambassador in reply to Lico]

Do send the rest of us a few thermal units!!! Blooming perishing here in northern Italy!

[Longtimer in reply to Lico]

Very jealous!.....rain on and off, and awful north wind!....

[PMRpro Ambassador in reply to Longtimer]

Not much wetness but a howling gale from the north!!

[Longtimer in reply to PMRpro]

Horrible, gale from the north!......and so dull with it!....

[PMRpro Ambassador in reply to Longtimer]

Dull here too. Not at all nice.

[Bcol in reply to PMRpro]

Thick frost in morning yesterday, rain all afternoon, cold, wet and miserable this morning.

[PMRpro Ambassador in reply to Bcol]

Could be worse I suppose - but on that note, the Italian forecast last night mentioned the white stuff for today!!! Wednesday is supposed to be the low point and then slowly, very slowly, the temp is to improve. Thank goodness - even disgusting on Lake Garda!

[Longtimer in reply to PMRpro]

Not in my favourite place, Lake Garda....not nice....

[Charlie1boy]

Very interesting that they are looking for alternatives. Not surprisingly, it’s a bit beyond me, but encouraging to learn about this work.

Thank you for posting.

[herdysheep]

Good to know there is something helpful on the horizon, albeit far away at the mo

[Songbird69]

Really interesting. Thanks Pro!

😊

[Kendrew]

Really encouraging to hear of yet another step forward in understanding how this disease both operates and responds to treatment. Thankyou for sharing.

[Bcol]

Thanks for the share, interesting and hopeful for future developments with less side effects.

[Missus835]

Encouraging to know that alternatives are being worked on; with less side effects as well. Hopefully, by the time it manifests, we won't need them and great for those who might. Thanks Pro. 😊

[Sharitone]

Interesting, and encouraging, though I don't understand At higher doses, it also inhibits the activity of the immune system, which makes it useful for medical purposes.

Our experience is that after a bit, even lower doses inhibit the return of immune activity.

[SheffieldJane]

Thank you for sharing. They’ll get there one day. Hurrah! for Erlangen University.

[PMRpro Ambassador in reply to SheffieldJane]

I spent the happiest 10 years of my life there!

[Smudge-1]

Thank you PMRpro. That’s a very interesting article and gives us hope of a less damaging inflammation controlling drug.🙂

[Predderman2020]

perfect - great explanation - good luck to them.

[Vrissi]

Thank you for sharing this article. It 's always good to understand a bit more about how our immune system works and why/when it doesn't. Better treatments for future sufferers I hope.

[Hopingsail]

Understanding how our systems work is the key to better treatments - as we are seeing in many fields. Encouraging.

[Flivoless]

Yes, that's exactly what I thought. 🤔

[Viveka]

Very interesting, thank you!

[Viv54]

Interesting read , thank you .

[Oh-my]

Thank you for posting. So good to hear there is research going on in that area. Looks promising

[Dinahmite]

Thank you.

[cranberryt]

Thank you. Very interesting!

[Myfoe]

thank you always helps my heart to know someone is working on a new drug or therapy which may someday help others our FDA kicks a new drug around for decades before approval but there is always hope… we had 70deg F one day over weekend and then it turned to several inches of snow and cold all week but sunshine this weekend again.. thanks again

[readingbooks]

Very interesting. It suggests too a reason why regular pain medications are largely ineffective in PMR . Here it alternates warm and sunny and grey and very wet, but we did recently have a complete eclipse of the sun which took my breath away !

[Frewen1]

how very interesting, thank you. Can’t come soon enough… and probably won’t. But one day…

[Purple-Owl]

Thanks PMRpro. Very interesting indeed. Adds to my understanding of what is going on in my body - though it's all so complicated I only to be truthful get the gist of it.

[rescuedogs]

My husbands dr gave him a drug called Kevzara. It’s FDA approved in the U.S for PMR. He gives himself a shot every other week and it’s working great. Fingers crossed. He is down to 1 mg of pred and so far feels great. If you can get Kevzara look into it. Good luck

[PMRpro Ambassador in reply to rescuedogs]

It isn't available in the UK.

[rescuedogs in reply to PMRpro]

I hope you get it soon

[PMRpro Ambassador in reply to rescuedogs]

As far as I know - not even on the horizon! And Prof Mackie doesn't expect it any time soon.