sarilumab

[piglette]

There was a short piece in the BMJ last week on PMR tapering with sarilumab which I thought might be of interest. I am afraid it is not a very good photograph, I am not the best at taking photos!

[yogabonnie]

I worry about changing drugs. frying pan into the fire. or the evil you know.. not sure of the expression haha. Is this a safe drug__ anyone using it for pmr??? are you thinking of trying it Piglet?? thanks!

[piglette in reply to yogabonnie]

No, I just thought that people might like to see the comment from the BMJ. There have been a few comments on sarilumab on this board in the past.

[yogabonnie in reply to piglette]

thanks I will ask my doc!! might be the ticket. ! always looking for that ticket.

[PMRpro Ambassador]

Not going to happen in the UK is it!!!!

nejm.org/doi/full/10.1056/N...

If you subscribe you get 2 free previews per month ...

Did the drug company get scared of the number discontinuing because of adverse effects?

But it is the Kevzara trial that the FDA has approved:

pharmacytimes.com/view/fda-...

[piglette in reply to PMRpro]

I must admit I was not that impressed with their statistics or their numbers, but I thought it may be of interest.

[PMRpro Ambassador in reply to piglette]

Must have been something else you'd think for the FDA to say yes.

[piglette in reply to PMRpro]

Totally agree.

[HeronNS]

Just read another article (about treatment for RA not PMR) which includes this:

"Despite these challenges, Kevzara, the first fully human monoclonal antibody (mAb) against IL-6, touts a stronger safety profile than Actemra, which is a recombinant human mAb and does not offer the same safety advantages of a fully human mAb. As such, GlobalData forecasts Kevzara to generate sales upward of $700 million across the 7MM by 2026, marking a significant opportunity for Sanofi and Regeneron, but not quite blockbuster."

pharmaceutical-technology.c...