Experiences with

Sarilumab

a bs tr ac t Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper

Sarilumab (Kevzara) is mentioned as possibly being released by NICE for PMR patients next year. I’m not sure how accurate that is.

Dorset lady advised me to open a new post regarding the yes/ no’s/ maybe s of actemra, kevzara, tocillizumab and sarilumab as medications for PMR. In stead of prednisolone/ prednison. Thanks Dorset lady. may I ask to add comments re. methotrexate too….

Hi, I am on both methotrexate and sarilumab injections but had to pause them because of an infection. Can anyone tell me whether it is ok to take them at the same time when I resume treatment? Thanks for any advice

I've been managing on 15mg per day and tried to cut down last week to 10mg but the pain was too much, I've injected again with Sarilumab this week so thought I would give it another go.

Kevzara (Sarilumab) IL-6 blocker was discussed by my Rheumatologist after the Leflunomide trial.

I have had to stop my Sarilumab jabs, yet again, because my white cells have dropped again. I have been off the drug for over three weeks now and have heard nothing since my last blood test. I expected to feel gradually worse without it but I don't.

I will be starting Sarilumab in the near future, I have searched for posts regarding this drug, but I would be interested to hear from anyone who had experience of it, the injecting doesn't worry me as I've done it before with Embrel. Many Thanks

There was a short piece in the BMJ last week on PMR tapering with sarilumab which I thought might be of interest. I am afraid it is not a very good photograph, I am not the best at taking photos!

So, my next step is to explore the possibility of moving to sarilumab, another IL-6 inhibitor, but that’s unlikely as I don’t think it’s been licensed for GCA yet. Unless anyone knows any different?

Hi All, I have a biologic injection (Kevzara/Sarilumab) that I need to take on a long journey lasting about 28 hours including train journeys and 2 air flights. In the past I have used an injection cooler which I bought from amazon which 2 small ice packs.

utm_source=news_medical_newsletter&utm_medium=email&utm_campaign=rheumatology_newsletter_3_november_2023 The study is using sarilumab, aka Kevzara - not the first study, I'm sure Dublin did a pilot study, but the SAPHYR study is bigger.

Having been on Sarilumab since March 2022, the effects started to wane and my Rheumy thinks I have developed antibodies to it. So he has added Leflunomide on top, since April 2023.

Two years ago I started Sarilumab SC injection once a fortnight which appears to be working . I really want to come off prednisolone, to try and get some weight off.

RA was diagnosed 4 years ago and I am now on Sarilumab jabs. I had a terrible flare around 4 weeks ago and couldn't get through to Rheumatology by any means. The pain in my hips was like fire and I had no real sleep for 2 weeks. The pain was also in my my bottom and groin.

Hi all, I've had RA since 2018 and I've had a cocktail of drugs since then, but I've now been on sarilumab for around 2 years and was doing okish up until a few months ago. I've rang Rheumy helpline last Wednesday and we have to leave a message but still had no reply.

I have been on Sarilumab for around a year and have gained a lot of abdominal fat. Is there a connection?

Anyway, yesterday I finally injected my first dose of Kevzera (Sarilumab) ..so hoping it brings some much needed relief soon and I can get off these oral steroids which I don't want to be taking for any longer than I need too..but they have helped a lot.

I've been on Sarilumab for just over a year. My bloods are very good but have had several bad flares. Just added Leflunomide v. low dose at present every other day. I'm itching everywhere even though I take antihistamine for hayfever. Worried the itching will increase as the dose is increased.

Does anyone have an opinion on sarilumab ? Recently approved in US for treatment of PMR. My rheumatologist suggested it to get off the prednisone. I am down to 1.5 mg per day. Going oh so slowly but not slowly enough for Rheumy! Always so appreciative of the advice and support of this forum.