LDN and PMR

[papadapadoo]

Almost three months into my use of low-dose naltrexone, in hopes of replacing prednisone eventually, I have learned that the power of LDN to combat inflammation, while real, is much less than prednisone, so that at 10mg of prednisone, LDN's ability to replace or even significantly supplement the steroid is doubtful. I still have hopes that LDN can take over when/if I am able to taper way down eventually. Meanwhile, I have noticed that the sciatica that has plagued me for years is in total remission, and the annoying peripheral neuropathy that afflicted my right ankle on and off for a couple of years is totally gone. In addition, since starting LDN I find that the world looks sunnier. So, no regrets and hope for more down the line.

[PMRpro Ambassador]

Good to hear!

[Hirwaen]

What is LND? Sounds interesting!!!!

[papadapadoo in reply to Hirwaen]

LDN is low-dose naltrexone. Google for info.

[redruth123]

Well that's a topic I havnt heard much about. Very interesting!. Did your doctor recommend it, or did you research it and ask your doctor to trial it?

[PMRpro Ambassador in reply to redruth123]

My daughter takes it for autoimmune thyroid problems and says there are loads of PMR patients on the website.

[redruth123 in reply to PMRpro]

Thanks PMRpro. Good to hear of the benefits people with various issues are receiving from it, especially in the autoimmune zone.

[papadapadoo in reply to redruth123]

My doctor had not heard of it. When he looked up "naltrexone," he found that at 8mg it was combined with another drug for weight loss. However, I showed him a paper from the NIH that testified that LDN was safe and might help my condition, and he readily wrote the prescription. (I have a terrific doctor.)

[redruth123 in reply to papadapadoo]

Thanks for your post and reply. I'm always interested to hear about drugs that help with pain and inflammation from various diagnoses - now have PMR, osteoarthritis, bursitis, etc etc.. With still (hopefully) a couple of decades of life left to enjoy, it's good to hear how others are managing or eliminating their symptoms and getting on with things. And good for you about having a terrific doctor.....not always easy to find. All the best.

[Megams]

~Well done - may this continue

My experience with this some years ago was used it transdermally - orally caused nausea even at the lowest dose.

Sadly not the successful outcome for me but sincerely hope all remains positive in your camp~

[Anon-mouse]

Been taking LDN for a few months now. Started at 1mg and now up to 4mg a day. Here is what I have noticed so far. The painful grip on my shoulders has gone away ( YAY! ) but if I do chores or gardening, I still experience pain and am still limited in how much I can do without paying for it. I still have fatigue, I take the LDN at night before bed. Have not noticed bad dreams like many others have experienced and no awful side effects like I have with pred, celebrex and hydroxychloroquine. I am highly sensitive to meds. I am still working on finding the right mg and understand you have to play with it a bit, so I am cautiously optimistic. I have osteoarthritis in my lower back from an old injury, not sure if it will do much for that. I would say overall my PMR pain level has gone from about a 7 to a 3 so I will celebrate for that!